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CDC6 — E2F1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yan et al., Proc Natl Acad Sci U S A 1998
:
Cdc6 is
regulated by
E2F and is essential for DNA replication in mammalian cells
Hateboer et al., Mol Cell Biol 1998
:
Furthermore,
E2F is
sufficient to induce expression of the endogenous
CDC6 gene even in the absence of de novo protein synthesis
Ohtani et al., Oncogene 1998
:
Expression of endogenous
Cdc6 was
induced by exogenous expression of
E2F ... Therefore, we concluded that the growth regulated expression of mammalian
Cdc6 was
mediated by
E2F ... Moreover, we demonstrated that exogenous overexpression of either HsCdc6 or HsOrc1 failed to induce DNA synthesis unlike overexpression of E2F1, even though
E2F1 induced both
Cdc6 and Orc1, suggesting that E2F may regulate the expression of another gene ( s ), besides Cdc6 and Orc1, required for induction of cellular DNA synthesis in mammalian cells