Gene interactions and pathways from curated databases and text-mining

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CD40 — IL5

Text-mined interactions from Literome

Bartholomé et al., J Interferon Cytokine Res 1999 : IFN-beta interferes with the differentiation of dendritic cells from peripheral blood mononuclear cells : selective inhibition of CD40 dependent interleukin-12 secretion
Kitagawa et al., Arthritis Rheum 1999 (Arthritis, Rheumatoid) : Differential regulation of rheumatoid synovial cell interleukin-12 production by tumor necrosis factor alpha and CD40 signals
Muraille et al., Blood 1999 : Anti-CD3epsilon treatment was found to induce a selective deficiency in the ability of spleen cells to produce bioactive interleukin-12 in response to CD40 stimulation
Tang et al., J Allergy Clin Immunol 2001 (Asthma...) : The aim of the present study was to define the roles of B7 and CD40 costimulatory signals delivered by AMs in regulating T-cell IL-5 responses in an allergen stimulated coculture system
Reider et al., J Allergy Clin Immunol 2002 (Hypersensitivity) : Production of IL-4, IL-5 , IL-10, IL-12, and IL-13 in response to CD40 ligation was measured with ELISA
Cattaruzza et al., J Biol Chem 2003 : Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40 mediated interleukin-12 synthesis in human endothelial cells
Moon et al., J Immunol 2004 (IgA Deficiency...) : IL-5 stimulation of wild-type B-1 cells, but not IL-5Ralpha ( -/- ) B-1 cells, enhances CD40 expression and augments IgM and IgG production after stimulation with anti-CD40 mAb
Pinzon-Charry et al., Neoplasia (New York, N.Y.) 2005 (Adenocarcinoma...) : Importantly, despite DR ( + ) IC 's poor responsiveness to inflammatory factors, in samples from healthy volunteers and breast cancer patients, CD40 ligation induced phenotypic maturation and interleukin 12 secretion, in turn generating more efficient T-cell responses
Zhou et al., J Immunol 2007 : Iloprost and cicaprost also suppressed LPS induced expression of CD86, CD40 , and MHC class II molecules by BMDCs and inhibited the ability of BMDCs to stimulate Ag-specific CD4 T cell proliferation and production of IL-5 and IL-13
Danese et al., Gut 2007 (Colitis...) : Engagement of CD40 on HIFs promoted the release of vascular endothelial growth factor ( VEGF ), interleukin-8 (IL-8) and hepatocyte growth factor (HGF)
Bose et al., Hum Immunol 2007 (Carcinoma, Squamous Cell...) : Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L mediated endogenous production of interleukin-12
Burdin et al., J Immunol 1995 : First, both CD40 and Ag receptor ( AgR ) cross linking induced purified tonsillar human B lymphocytes to secrete the same pattern of cytokines, including IL-1 beta, IL-6, IL-10, granulocyte-macrophage-CSF, and TNF-alpha, whereas IL-1 alpha, IL-2, IL-3, IL-4, IL-5 , IL-7, granulocyte (G)-CSF, or IFN-gamma were not detected
Kennedy et al., Eur J Immunol 1996 : CD40/CD40 ligand interactions are required for T cell dependent production of interleukin-12 by mouse macrophages
Cella et al., J Exp Med 1996 : Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity : T-T help via APC activation
Peng et al., Eur J Immunol 1996 : In this study we demonstrate that upon stimulation of human peripheral blood T cells through the T cell receptor (TCR)/CD3 complex, CD40/CD40L interaction strongly enhances the production of Th1 cytokines such as interleukin (IL)-2 and interferon (IFN)-gamma and Th2 cytokines such as IL-4, IL-5 and IL-10 by a direct effect on T cells ... In this study we demonstrate that upon stimulation of human peripheral blood T cells through the T cell receptor (TCR)/CD3 complex, CD40/CD40L interaction strongly enhances the production of Th1 cytokines such as interleukin (IL)-2 and interferon (IFN)-gamma and Th2 cytokines such as IL-4, IL-5 and IL-10 by a direct effect on T cells
Yoshimoto et al., Eur J Immunol 1997 : Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaB
Séguin et al., J Infect Dis 1999 : Sensitized lymphocytes and CD40 ligation augment interleukin-12 production by human dendritic cells in response to Toxoplasma gondii