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BCL10 — CD40

Text-mined interactions from Literome

Lee et al., Proc Natl Acad Sci U S A 1999 (Lymphoma, B-Cell) : NF-kappaB mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes ... In addition to Bcl-x , a known CD40 regulated antiapoptotic molecule, we identified a related antiapoptotic molecule, A1/Bfl-1, as a CD40-inducible gene ... Inhibition of the NF-kappaB pathway by overexpression of a dominant-active inhibitor of NF-kappaB abolished CD40 induced up-regulation of both the Bfl-1 and Bcl-x genes and also eliminated the ability of CD40 to rescue Fas induced cell death
Taylor et al., Endocr Relat Cancer 1999 (Lymphoma, B-Cell...) : CD40 receptor ligation resulted in increased levels of Bcl-XL
Andjelic et al., J Immunol 2000 : However, the PI-3K/NF-kappaB pathway is still required for CD40 induced Bcl-X gene expression
Hirai et al., Cell Death Differ 2004 : Expression of Bcl-xL and A1, antiapoptotic members of the Bcl-2 family, is enhanced by CD40 ligation, and is suggested to mediate CD40 induced B-cell survival
Ke et al., Mol Ther 2004 (Liver Diseases...) : Ad-CD40Ig reduced frequency of TUNEL+ cells and pro-apoptotic Caspase-3, but enhanced antioxidant HO-1 and anti-apoptotic Bcl-2/Bcl-xl expression
Zhou et al., Apoptosis 2005 (Lymphoma, B-Cell...) : CD40 activation stimulated both anti-apoptotic Bcl-XL and pro-apoptotic Bax mRNA synthesis in the Daudi cell line ; CD40 activation increased the Bax mRNA level but had no effect on the Bcl-XL mRNA level in the XG2 cell line
Vaitaitis et al., PloS one 2008 : CD40 engagement of Th40 cells induces Nf-kappaB DNA binding activity and anti-apoptotic Bcl-X ( L ) expression in all three mouse strains
Huang et al., Med Oncol 2011 (Uterine Cervical Neoplasms) : Furthermore, CD40 activation blocked SiHa in the S phase, stimulated proapoptotic Bax and inhibited antiapoptotic Bcl-XL mRNA synthesis in the SiHa cell
Ishida et al., J Immunol 1995 : CD40 signaling mediated induction of Bcl-XL , Cdk4, and Cdk6
Wang et al., J Immunol 1995 (Lymphoma, B-Cell) : Induction of bcl-x by CD40 engagement rescues sIg induced apoptosis in murine B cells ... bcl-x expression is strongly enhanced by CD40 receptor engagement, while there is little or no induction by sIg cross linking
Zhang et al., Mol Cell Biol 1994 (Leukemia, Lymphocytic, Chronic, B-Cell...) : In contrast to I kappa B alpha ( MAD3 ), BCL3 does not cause NF-kappa B p50 to be retained in the cytoplasm ; instead, in cotransfection assays, it alters the subnuclear localization of p50
Tuscano et al., Blood 1996 : Bcl-x rather than Bcl-2 mediates CD40 dependent centrocyte survival in the germinal center
Denfeld et al., Eur J Immunol 1996 (Psoriasis...) : Furthermore, ligation of CD40 via soluble gp39, the CD40 ligand, enhances intercellular adhesion molecule (ICAM)-1 and Bcl-x up-regulation on IFN-gamma stimulated KC, but not lymphocyte function associated antigen ( LFA)-3, B7-2, HLA-DR, or Fas expression
Fang et al., Am J Physiol 1997 : CD40 signaling led to a rapid increase in the expression of the apoptosis inhibitory protein Bcl-xL
An et al., Cell Immunol 1997 (Burkitt Lymphoma) : This CD40 potentiated Fas triggered growth inhibition and apoptosis occurs in the presence of CD40 induced expression of the anti-apoptotic proteins Bcl-xL and Bcl-2
Curnock et al., Cell Immunol 1998 (Burkitt Lymphoma) : The LY-mediated induction of growth inhibition and apoptosis occurs in the presence of the CD40 induced anti-apoptotic protein Bcl-XL ... Taken together these data indicate that the CD40 of Ramos BL B cells is linked to PI3-kinase independent and -dependent routes of survival : CD40 mediated inhibition of AgR triggered caspase-3-like activity, PARP cleavage, and CD40 triggered Bcl-XL expression are PI3-kinase independent, whereas PI3-kinase is critical for CD40 mediated rescue of this cellular population from AgR triggered growth inhibition, caspase-3 processing, and apoptosis