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IL8 — MKNK1
Text-mined interactions from Literome
Cherla et al., J Leukoc Biol 2006
(MAP Kinase Signaling System) :
The MAPK inhibitors or
Mnk1 inhibitor
blocked soluble interleukin (IL)-1beta and
IL-8 production or release by 73-96 %
Fukunaga et al., EMBO J 1997
:
Further,
MNK1 was activated upon
stimulation of HeLa cells with 12-O-tetradecanoylphorbol-13-acetate, fetal calf serum, anisomycin, UV irradiation, tumor necrosis factor-alpha,
interleukin-1beta , or osmotic shock, and the activation by these stimuli was differentially inhibited by the MEK inhibitor PD098059 or the p38 MAP kinase inhibitor SB202190