Gene interactions and pathways from curated databases and text-mining

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CSK — IL8

Text-mined interactions from Literome

Trevino et al., Cancer Res 2005 (Adenocarcinoma...) : In contrast, pharmacologic inhibition of endogenous c-Src kinase activity or small interfering RNA mediated `` knockdown '' of c-Src expression in L3.6pl cells with high Src expression and activity caused significant decreases in IL-8 production ( P < 0.005 )
Kanczkowski et al., Horm Metab Res 2007 (Adrenal Cortex Neoplasms) : Pam3CSK4 and LTA-TLRs ligands associated with microdomains induce IL8 production in human adrenocortical cancer cells
Rydberg et al., Immunology 2009 (Carcinoma, Squamous Cell...) : Poly ( I:C ) induced a small increase in IL-1beta, IL-6 and IL-8 production in HNECs, while Pam ( 3 ) CSK ( 4 ) increased viability
Into et al., Cell Immunol 2010 (Bacterial Infections...) : LL-37 modestly attenuated the expression of IL6 and IL8 induced by the TLR2/TLR1 ligand Pam ( 3 ) CSK ( 4 ), but did not affect the expression induced by the TLR2/TLR6 ligand MALP-2
Ultaigh et al., Arthritis Res Ther 2011 (Arthritis, Rheumatoid) : OPN301 significantly decreased Pam3CSK4 induced cytokine production of tumour necrosis factor alpha ( TNF-a ), IL-1ß, IL-6, interferon ( IFN ) -? and IL-8 compared to IgG control in RA PBMCs and SFMCs cultures ( all P < 0.05 )
Morandini et al., J Periodontol 2013 (Inflammation) : Knockdown of TLR2 decreased IL-6 and IL-8 in response to P. gingivalis LPS, or Pam2CSK4 and Pam3CSK4, in a similar manner in both fibroblasts subpopulations
Henrick et al., PloS one 2012 (HIV Infections...) : sTLR2 immunodepleted BM, versus mock depleted BM, incubated with Pam ( 3 ) CSK ( 4 ) lead to significant increases in IL-8 production in a TLR2-dependant fashion in U937, HEK293-TLR2, and Caco-2