Chandramohan et al., J Immunol 2004
:
We demonstrate that pharmacologic inhibitors of PI3K or BCR engagement lead to decreased inactive cytoplasmic levels and increased active functional nuclear FOXO3a Bilancio et al., Blood 2006
:
p110delta activity is indispensable for BCR induced DNA synthesis and phosphorylation of Akt/protein kinase B (PKB), forkhead transcription factor/forkhead box O3a (FOXO3a) , and p70 S6 kinase (p70 S6K), with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk )
Birkenkamp et al., J Biol Chem 2007
(Cell Transformation, Neoplastic...) :
Inhibition of Bcr-Abl by the chemical inhibitor STI571 resulted in activation of FOXO3a and down-regulation of Id1 expression
Hinman et al., Int Immunol 2009
:
We now show that BCR induced down-regulation of Foxo3 and Foxo4 mRNA expression occurs via distinct mechanisms from those established for Foxo1