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CD40 — IL8

Text-mined interactions from Literome

von Leoprechting et al., Cancer Res 1999 (Melanoma) : CD40 ligation on MM by CD40L transfected murine L-cells or by a soluble CD40L fusion protein up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6, IL-8 , tumor necrosis factor-a, and granulocyte macrophage colony stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB
Bartholomé et al., J Interferon Cytokine Res 1999 : IFN-beta interferes with the differentiation of dendritic cells from peripheral blood mononuclear cells : selective inhibition of CD40 dependent interleukin-12 secretion
Kitagawa et al., Arthritis Rheum 1999 (Arthritis, Rheumatoid) : Differential regulation of rheumatoid synovial cell interleukin-12 production by tumor necrosis factor alpha and CD40 signals
Muraille et al., Blood 1999 : Anti-CD3epsilon treatment was found to induce a selective deficiency in the ability of spleen cells to produce bioactive interleukin-12 in response to CD40 stimulation
Thienel et al., Cell Immunol 1999 : Utilizing specific ELISAs, we confirmed that CD40 ligation induces HUVEC to secrete IL-8 , MCP-1, and RANTES, but not MIP-1alpha
Sugiura et al., J Immunol 2000 (Dermatomyositis...) : Increased CD40 expression on muscle cells of polymyositis and dermatomyositis : role of CD40-CD40 ligand interaction in IL-6, IL-8 , IL-15, and monocyte chemoattractant protein-1 production
Propst et al., J Immunol 2000 (Inflammation) : The results show that airway epithelial cells express CD40 and that engagement of epithelial CD40 induces a significant increase in expression of the chemokines RANTES, monocyte chemoattractant protein ( MCP-1 ), and IL-8 and the adhesion molecule ICAM-1
Willermain et al., Invest Ophthalmol Vis Sci 2000 : Although interferongamma enhanced IL-6 and IL-8 production, CD40 triggering of IFNgamma activated hRPE cells did not induce IL-12 secretion
Schwabe et al., J Immunol 2001 : CD40 activation increases the secretion of IL-8 and monocyte chemoattractant protein-1 by HSCs 10- and 2-fold, respectively
Koumas et al., Am J Pathol 2001 : Engagement of CD40 in the Thy 1 ( + ) subpopulation induced IL-6, IL-8 , and MCP-1
Li et al., American journal of physiology. Renal physiology 2002 : CD40 ligation stimulates MCP-1 and IL-8 production, TRAF6 recruitment, and MAPK activation in proximal tubule cells ... Engagement of CD40 by CD154 stimulated interleukin-8 (IL-8) and monocyte chemoattractant protein-1 ( MCP-1 ) production, which proceeded via receptor activation of the extracellular signal regulated kinase ( ERK ) 1/2, stress activated protein kinase ( SAPK ) /c-Jun NH ( 2 ) -terminal kinase ( JNK ), and p38 mitogen activated protein kinase ( MAPK ) pathways
Companjen et al., Int Immunol 2002 : In vitro studies have shown that CD40 ligation on human keratinocytes results in the production of IL-6 and IL-8 as well ... IL-6, IL-8 , tumor necrosis factor (TNF)-alpha, IL-12 and IL-1 beta were induced upon CD40 ligation and IFN-gamma stimulation, while IL-10 could be induced by CD40 ligation alone and was reduced again by the addition of IFN-gamma ... Since CD40 ligation on monocytes and dendritic cells in vitro results in the secretion of IL-1, which is pre stored in high concentrations in normal human keratinocytes, we subsequently investigated whether CD40 induced IL-6 and IL-8 production in skin is mediated via IL-1 ... Indeed IL-1 receptor antagonist inhibited the CD40 ligation induced IL-6 and IL-8 production, while TNF-alpha and IL-10 production were not affected ... These data show that CD40 ligation induced secretion of IL-6 and IL-8 , but not TNF-alpha and IL-10, is partially mediated via IL-1 and that IL-1 plays a prominent role in the inflammatory response initiated by CD40 ligation in intact human skin
Cattaruzza et al., J Biol Chem 2003 : Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40 mediated interleukin-12 synthesis in human endothelial cells
Fukasawa et al., Eur J Immunol 2003 (Scleroderma, Systemic) : Ligation of CD40 by recombinant human CD154 ( 0.5-2 microg/ml ) resulted in increased production of IL-6, IL-8 , and monocyte chemoattractant protein-1 in SSc fibroblasts in a dose dependent manner, whereas these phenomena were not shown in normal fibroblasts even with the addition of CD154
Man et al., Kidney Int 2003 : In contrast, the secretion of the neutrophil chemoattractant IL-8 , induced by CD40 ligation or by the combination of IL-1 and TNF-alpha, was reduced in the presence of IFN-gamma
Li et al., American journal of physiology. Renal physiology 2004 (MAP Kinase Signaling System) : We conclude that in human renal proximal tubule epithelial cells, CD40 and its downstream MAPK signaling proteins are located in membrane rafts and that disruption of caveolae or dislodgment of signaling proteins from the CSD diminishes MAPK activation and IL-8 and MCP-1 production in these cells
Girouard et al., Mol Immunol 2005 : Requirement of the extracellular cysteine at position six for CD40/CD40 dimer formation and CD40 induced IL-8 expression ... To determine the potential residue ( s ) involved in disulfide bonds formation and subsequent CD40 induced IL-8 expression, we generated a CD40 mutant in which the extracellular cysteine 6 was replaced by a glutamine ( CD40-C6Q ) ... CD40 induced IL-8 mRNA expression and protein synthesis were studied in stably transfected HEK 293 cells that were sorted out along with similar levels of expression of wild type ( CD40-WT ) and CD40-C6Q molecules ... Abolishment of disulfide linked CD40/CD40 dimers in these transfected cells was sufficient to inhibit CD40 induced mRNA expression and secretion of IL-8
Cao et al., Oral Oncol 2005 (Head and Neck Neoplasms...) : CD40 ligation specifically increased the secretion of IL-8 , VEGF and PGE ( 2 ) but not IL-6, IL-10, FasL, GM-CSF, or TGFalpha
Pinzon-Charry et al., Neoplasia (New York, N.Y.) 2005 (Adenocarcinoma...) : Importantly, despite DR ( + ) IC 's poor responsiveness to inflammatory factors, in samples from healthy volunteers and breast cancer patients, CD40 ligation induced phenotypic maturation and interleukin 12 secretion, in turn generating more efficient T-cell responses
Danese et al., Gut 2007 (Colitis...) : Engagement of CD40 on HIFs promoted the release of vascular endothelial growth factor ( VEGF ), interleukin-8 (IL-8) and hepatocyte growth factor (HGF)
Reyes-Moreno et al., J Biol Chem 2007 : Mutagenesis and biochemical analyses revealed that ( a ) the integrity of the detergent-resistant membranes is necessary for dl-CD40 homodimer formation, ( b ) the cytoplasmic Cys ( 238 ) of CD40 is the target for the de novo disulfide oxidation induced by receptor oligomerization, and ( c ) dl-CD40 homodimer formation is required for CD40 induced interleukin-8 secretion
Ade et al., Toxicological sciences : an official journal of the Society of Toxicology 2007 : In this work, we showed that NiSO ( 4 ) induced the expression of HLA-DR, CD83, CD86, and CD40 and the production of interleukin (IL)-8, IL-6, and IL-12p40 in human DCs, whereas DNCB induced mainly the expression of CD83 and CD86 and the production of IL-8
Bose et al., Hum Immunol 2007 (Carcinoma, Squamous Cell...) : Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L mediated endogenous production of interleukin-12
Li et al., American journal of physiology. Renal physiology 2009 (MAP Kinase Signaling System) : Activation of the CD40 receptor by its cognate ligand, CD154, results in interleukin-8 (IL-8) and monocyte chemoattractant protein-1 ( MCP-1 ) production and increased intercellular adhesion molecule-1 ( ICAM-1 ) expression in proximal tubule cells ( PTCs ) ... This cascade of events is independent of CD40/CD154 mediated IL-8 stimulation and ICAM-1 production and serves to amplify the inflammatory response
Hwang et al., Invest Ophthalmol Vis Sci 2009 (Graves Ophthalmopathy) : In the present study the authors investigated the role of CD40 ligation on macrophage chemoattractant protein-1 ( MCP-1 ), IL-6, and IL-8 expression in fibroblasts from patients with TAO
Borcherding et al., Am J Pathol 2010 (Inflammatory Bowel Diseases) : CD40 ligation by CD40L transfected murine fibroblasts or soluble CD40L increased the secretion of IL-8 in IFN-gamma pretreated HT29 cells
Gruss et al., Blood 1994 (Hodgkin Disease...) : We found that recombinant CD40 ligand (CD40L) induced interleukin-8 (IL-8) secretion and enhanced IL-6, TNF, and lymphotoxin-alpha ( LT-alpha/TNF-beta ) release from cultured H-RS cells
Kennedy et al., Eur J Immunol 1996 : CD40/CD40 ligand interactions are required for T cell dependent production of interleukin-12 by mouse macrophages
Cella et al., J Exp Med 1996 : Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity : T-T help via APC activation
Péguet-Navarro et al., J Immunol 1997 : Using CD40-ligand transfected L cells (CD40Lc), we demonstrated that CD40 triggering results in an enhanced secretion of both IL-8 and TNF-alpha by cultured epidermal basal cells, suggesting that CD40-CD40L interactions may play a role in amplifying the cutaneous inflammatory reactions
Yoshimoto et al., Eur J Immunol 1997 : Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaB
Revy et al., Eur J Immunol 1998 (Immunologic Deficiency Syndromes) : We show that the CD40 induced production of IL-6, IL-8 and TNF-alpha by monocytes, and IL-12 by dendritic cells, and expression of the activation markers CD83, the costimulatory molecules CD86 and CD80, and HLA-DR antigens were all similar in patient and control cells
Snijders et al., Int Immunol 1998 : The two-signal requirement proved unique for the production of IL-12, since either CD40 engagement or LPS was sufficient for the efficient production of tumor necrosis factor-alpha, IL-8 and the p40 subunit of IL-12, and may be considered as a safety mechanism for optimal control of potentially harmful T ( h ) 1 responses
Séguin et al., J Infect Dis 1999 : Sensitized lymphocytes and CD40 ligation augment interleukin-12 production by human dendritic cells in response to Toxoplasma gondii