Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
PIK3CG
→
GRN
(increases, GRN Activity, PIK3CG Activity)
Evidence: Migration in response to 1.5 nM progranulin was prevented by 10 micro M PD098059 and 10 nM wortmannin inhibitors, respectively, of MAPK kinase and PI3 kinase indicating that both the ERK and PI3 kinase pathways are essential for progranulin mediated migration.