Gene interactions and pathways from curated databases and text-mining

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GRN — PIK3CG

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: PIK3CG → GRN (increases, GRN Activity, PIK3CG Activity)
    Evidence: Migration in response to 1.5 nM progranulin was prevented by 10 micro M PD098059 and 10 nM wortmannin inhibitors, respectively, of MAPK kinase and PI3 kinase indicating that both the ERK and PI3 kinase pathways are essential for progranulin mediated migration.