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IL8 — NR4A2

Text-mined interactions from Literome

Davies et al., Journal of inflammation (London, England) 2005 : Using microarray analysis we show that elevated levels of Nurr1 leads to increased gene expression of pro-inflammatory genes : IL-8 , Amphiregulin and Kit ligand in a model cell line
Bonta et al., Arterioscler Thromb Vasc Biol 2006 (Atherosclerosis...) : Lentiviral overexpression of Nur77, Nurr1 , or NOR-1 reduces expression and production of interleukin (IL)-1beta and IL-6 proinflammatory cytokines and IL-8 , macrophage inflammatory protein-1alpha and -1beta and monocyte chemoattractant protein-1 chemokines
Aherne et al., Mol Immunol 2009 (Arthritis) : Ectopic expression of NR4A2 leads to robust changes in endogenous IL-8 mRNA levels and co-treatment with TNF-alpha results in significant ( p < 0.001 ) secretion of IL-8 protein ... Transcriptional effects of NR4A2 on the human IL-8 promoter are enhanced in the presence of TNF-alpha, suggesting molecular crosstalk between TNF-alpha signalling and NR4A2 ... Collectively, these data delineate an important role for NR4A2 in modulating IL-8 expression and reveal novel transcriptional responses to TNF-alpha in human inflammatory joint disease