Ghosh et al., Arthritis Rheum 2004
(Fibrosis...) :
Ligand induced activation of fibroblast PPAR gamma had no effect on protein expression of cellular Smad3 or Smad7
Ghosh et al., FASEB J 2009
:
In contrast, the interaction between activated Smad2/3 and the transcriptional coactivator and histone acetyltransferase p300 induced by TGF-beta, and the accumulation of p300 on consensus Smad binding DNA sequences and histone H4 hyperacetylation at the COL1A2 locus, were all prevented by PPAR-gamma