◀ Back to HSP90AA1
HSP90AA1 — NFKBIA
Pathways - manually collected, often from reviews:
-
WikiPathways EBV LMP1 signaling:
Complex of IKBKG-CHUK-IKBKB-HSP90AA1
→
Complex of NFKBIA-NFKB1-RELA
(activation)
Text-mined interactions from Literome
Shi et al., Mol Immunol 2009
:
Silencing
Hsp90 expression through RNA interference ( RNAi ) also
down-regulated TAK1, as well as attenuated IL-1beta induced phosphorylation of c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs, and degradation of
IkappaBalpha
Kim et al., Mol Cancer Res 2008
(Glioma) :
Here, we report that the
Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin ( 17-AAG ) blocks MMP-9 secretion and that HA-induced nuclear factor-kappaB (NF-kappaB) activation is
mediated by
IkappaB kinase , which phosphorylates the NF-kappaB inhibitor IkappaBalpha and promotes its degradation