Gene interactions and pathways from curated databases and text-mining

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HSP90AA1 — NFKBIA

Pathways - manually collected, often from reviews:

  • WikiPathways EBV LMP1 signaling: Complex of IKBKG-CHUK-IKBKB-HSP90AA1 → Complex of NFKBIA-NFKB1-RELA (activation)

Text-mined interactions from Literome

Shi et al., Mol Immunol 2009 : Silencing Hsp90 expression through RNA interference ( RNAi ) also down-regulated TAK1, as well as attenuated IL-1beta induced phosphorylation of c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs, and degradation of IkappaBalpha
Kim et al., Mol Cancer Res 2008 (Glioma) : Here, we report that the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin ( 17-AAG ) blocks MMP-9 secretion and that HA-induced nuclear factor-kappaB (NF-kappaB) activation is mediated by IkappaB kinase , which phosphorylates the NF-kappaB inhibitor IkappaBalpha and promotes its degradation