Gene interactions and pathways from curated databases and text-mining

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JUN — PLG

Text-mined interactions from Literome

Olman et al., Blood 1999 : Fibrin fragment induction of plasminogen activator inhibitor transcription is mediated by activator protein-1 through a highly conserved element
Yoshizaki et al., Histol Histopathol 2002 (Carcinoma...) : LMP-1 down-regulates expression of E-cadherin, induces matrix metalloproteinase-9 and urokinase type-plasminogen activator through activation of NF-kappaB and AP-1 , and enhances cell motility via ets-1 activation
Syrovets et al., Thromb Haemost 2002 (Inflammation) : Ciglitazone activates PPAR gamma as shown by a novel surface plasmon resonance analysis and inhibits the plasmin induced activation of NF-kappa B and AP-1
Cuevas et al., Oncogene 2005 : Both FGF-2 and phorbol ester-inducible urokinase-type plasminogen activator ( uPA ) expression requires AP-1 binding to an enhancer element in the uPA promoter, and we have previously shown that FGF-2 or PMA induction of uPA expression is strongly dependent on MEKK1
De Sousa et al., Biochem Biophys Res Commun 2005 (MAP Kinase Signaling System) : Furthermore, Plg/Pla also stimulated AP-1 and EGR-1 DNA binding activities, which were abrogated by pharmacological inhibition of MEK
Kim-Mitsuyama et al., Gene Ther 2006 (Cardiomegaly...) : Ad.DN-c-Jun , which was transferred to the heart 2 days before AngII infusion, prevented cardiac hypertrophy ( P < 0.01 ), decreased p70S6 kinase phosphorylation ( P < 0.05 ), and suppressed cardiac gene expression of brain natriuretic peptide, collagen I, III, and IV, monocyte chemoattractant protein-1 ( MCP-1 ) and plasminogen activator inhibitor-1 ( PAI-1 ) ( P < 0.01 )
Deng et al., Mol Biol Cell 2006 : MEKK1 ablation or down-regulation by interfering RNA significantly delays skin wound closure and impairs activation of Jun NH2-terminal kinases, induction of plasminogen activator inhibitor (PAI)-1 , and restoration of cell-cell junctions of the wounded epidermis
Mann et al., Proc Natl Acad Sci U S A 1999 (Adenocarcinoma...) : There are four genes affected by beta-catenin overexpression ; three overexpressed genes code for two components of the AP-1 transcription complex, c-jun and fra-1, and for the urokinase-type plasminogen activator receptor ( uPAR ), whose transcription is activated by AP-1