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CTNNB1 — EGF
Pathways - manually collected, often from reviews:
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NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
EGFR/EGFR/EGF/EGF complex (EGFR-EGF)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, activates)
Miravet et al., Mol Cell Biol 2003, Hoschuetzky et al., J Cell Biol 1994, Shibamoto et al., Cell adhesion and communication 1994
Evidence: assay, physical interaction
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NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
EGF (EGF)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Qian et al., EMBO J 2004, Hoschuetzky et al., J Cell Biol 1994, Takahashi et al., Exp Cell Res 1996
Evidence: assay, physical interaction
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
EGFR/EGFR/EGF/EGF complex (EGFR-EGF)
(modification, inhibits)
Qian et al., EMBO J 2004, Hoschuetzky et al., J Cell Biol 1994, Takahashi et al., Exp Cell Res 1996
Evidence: assay, physical interaction
Text-mined interactions from Literome
Mizushima et al., Cancer Res 2002
(Esophageal Neoplasms) :
Wnt-1 but not
epidermal growth factor induces
beta-catenin/T-cell factor dependent transcription in esophageal cancer cells
Al Moustafa et al., Lung Cancer 2002
(Carcinoma...) :
In contrast,
epidermal growth factor (EGF) or heparin binding EGF-like growth factor ( HB-EGF )
induces the epithelial-like to fibroblastoid conversion of A549 and H322 cell lines, slightly reduces the expression of E-cadherin and
beta-catenin , but not alpha- and gamma-catenins, and stimulates cell motility
Müller et al., Exp Cell Res 2002
(Carcinoma...) :
Hepatocyte growth factor (HGF) and
epidermal growth factor (EGF) induce
beta-catenin signaling under conditions where they stimulate cell motility
Cheon et al., Exp Cell Res 2004
(Cicatrix) :
EGF and TGF-beta1 significantly
increased beta-catenin protein levels and transcriptional activity, whereas beta-catenin mRNA expression was unaffected
Lu et al., Cell cycle (Georgetown, Tex.) 2004
(Neoplasms) :
In response to EGF, tumor cells overexpressing
EGF receptor display GSK-3beta independent
activation of
beta-catenin , which may result from a combination of effects-EGF stimulated, caveolin-1 dependent internalization of E-cadherin, resulting in release of beta-catenin from cell-cell contacts, and EGF induced downregulation of caveolin-1, relieving the inhibition of signaling molecules sequestered by caveolin-1 at caveolae
Sheth et al., Alcohol Clin Exp Res 2004
:
EGF effectively
prevented acetaldehyde induced reorganization of actin cytoskeleton and the interaction of occludin, ZO-1, E-cadherin, and
beta-catenin with the actin cytoskeleton
Shiozaki et al., Br J Cancer 1995
(Carcinoma, Squamous Cell...) :
Finally, we examined tyrosine phosphorylation of E-cadherin and alpha- and beta-catenin, and observed tyrosine phosphorylation of
beta-catenin induced by
EGF
Hoschuetzky et al., J Cell Biol 1994
:
EGF induces an immediate tyrosine phosphorylation of
beta-catenin and gamma-catenin ( plakoglobin )
Shiozaki et al., Hum Cell 1996
(Esophageal Neoplasms...) :
Finally, we observed tyrosine phosphorylation of
beta-catenin induced by
EGF