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FOS — IL1B

Pathways - manually collected, often from reviews:

• KEGG Toll-like receptor signaling pathway: FOS/JUN → IL1B (protein-protein, expression)

Text-mined interactions from Literome

Liu et al., J Neurosci 2000 : However, pretreatment with oATP downregulated activation of NF-kappaB and AP-1 by IL-1beta or TNFalpha
Jeon et al., Immunopharmacology 2000 : Dexamethasone inhibits IL-1 beta gene expression in LPS stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and AP-1 activation
Hungness et al., Shock 2000 : The effect of IL-1beta on AP-1 activity in the enterocyte and the potential role of AP-1 in enterocyte IL-6 production are not known ... Geldanamycin, which has been shown in studies to inhibit AP-1 activation, blocked IL-1beta induced AP-1 luciferase gene activation and IL-6 production ... These results suggest that the AP-1 family of transcription factors is activated by IL-1beta in human enterocytes and that AP-1 may at least in part regulate IL-6 production in these cells
Hamid et al., Cytokine 2000 : The IL-1beta stimulated the collagenase-CAT and AP-1-CAT activities in a dose dependent manner with respect to the amount of DNA used in transfections
Ek et al., J Comp Neurol 2000 : Combined hybridization histochemical detection of EP3R mRNA with immunolocalization of IL-1beta induced Fos protein expression identified cytokine-sensitive, EP3R positive cells in the medial NTS, rostral VLM, and, to a lesser extent, aspects of the MPO
Lucio-Cazana et al., J Am Soc Nephrol 2001 : These data suggested that ( 1 ) constitutive and IL-1beta-inducible expression of MCP-1 was differently regulated by AP-1 and NF-kappaB and ( 2 ) t-RA inhibited selectively the constitutive expression of MCP-1 via intervention in the AP-1 pathway
Fahmi et al., Osteoarthritis Cartilage 2002 : Interestingly, 15d-PGJ ( 2 ) reduced both basal and IL-1beta induced AP-1 binding activity
He et al., Zhonghua Yi Xue Za Zhi 2001 (Pulmonary Disease, Chronic Obstructive) : Enhancement of activity of NF kappa B and AP-1 may positively regulate the production of IL-8 and IL-1 beta in the airflow obstruction
Patel et al., J Interferon Cytokine Res 2002 (Melanoma) : Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta induced NF-kappaB, but not AP-1 , leading to inhibition of IL-8 expression
Benderdour et al., J Rheumatol 2002 (Osteoarthritis) : Of note, in OA chondrocytes, IL-17 and IL-1beta induced collagenase-3 production through AP-1 occurred with differential protein complexes : IL-17 stimulation resulted in FosB activation, while IL-1beta stimulated c-Fos ... We demonstrated that IL-17 and IL-1beta induced collagenase-3 production in OA chondrocytes mainly through AP-1 mediated transcriptional activity but with differential protein complexes, suggesting that some AP-1 proteins play a pivotal role in the different cytokine responses in terms of collagenase-3 production
Lee et al., J Immunol 2003 : IL-1 beta increased NF-kappa B and AP-1 activity and both transcription factors mediated IL-1 beta induced MCP-1 expression in mesangial cells ... BMP-7 inhibited IL-1 beta induced AP-1 activity in a concentration dependent manner
Crane et al., Eur J Neurosci 2003 : To identify brain regions that might mediate the effect of medial prefrontal cortex lesions on hypothalamic-pituitary-adrenal axis responses to systemic interleukin-1beta, we next mapped the effects of similar lesions on interleukin-1beta induced Fos expression in regions previously shown to regulate the hypothalamic-pituitary-adrenal axis response to this stressor
Bamba et al., Am J Physiol Gastrointest Liver Physiol 2003 : The EMSAs demonstrated that both IL-1beta and TGF-beta1 induced AP-1 activation within 2 h after stimulation, and a blockade of AP-1 activation by the recombinant adenovirus containing a dominant negative c-Jun markedly reduced the IL-1beta- and TGF-beta1 induced IL-11 mRNA expression
Tjwa et al., Am J Physiol Gastrointest Liver Physiol 2003 : IL-1beta induced Fos expression in enteric neurons and also in enteric glia in the ileum and colon
Martin et al., Inflammation 2003 (MAP Kinase Signaling System...) : Rhein inhibits interleukin-1 beta induced activation of MEK/ERK pathway and DNA binding of NF-kappa B and AP-1 in chondrocytes cultured in hypoxia : a potential mechanism for its disease modifying effect in osteoarthritis
Crane et al., J Comp Neurol 2003 : Unilateral ibotenic acid lesions encompassing the ventral BNST significantly reduced both IL-1beta induced increases in Fos immunoreactivity in corticotropin releasing factor (CRF) cells of the hypothalamic paraventricular nucleus ( PVN ) and corresponding increases in adrenocorticotropic hormone ( ACTH ) secretion ... In further studies, we examined the functional connections between PVN, BNST, and CeA by combining retrograde tracing with mapping of IL-1beta induced increases in Fos in BNST and CeA cells
Mendes et al., Cell Biol Toxicol 2003 (Inflammation) : Hydrogen peroxide mediates interleukin-1beta induced AP-1 activation in articular chondrocytes : implications for the regulation of iNOS expression
Chuen et al., J Lab Clin Med 2004 : In this study, we investigated the possible direct effects of IL-1beta on the expression of thrombopoietin (TPO) and transcription factors c-Jun, c-Fos , GATA-1, and p45 nuclear factor-E2 (NF-E2) in MK cell lines CHRF and Meg-01
Bian et al., Invest Ophthalmol Vis Sci 2004 : Blockade of PI3K/Akt abolished IL-1beta induced nuclear translocation of AP-1 , whereas the induction of IkappaB degradation was unchanged
Hwang et al., Oncogene 2004 (Stomach Neoplasms) : Electrophoretic mobility shift assay confirmed that IL-1beta increased the DNA binding activity of AP-1 and NF-kappaB
Buller et al., J Neuroimmunol 2004 : These results suggest that the parabrachial nucleus plays a critical role in interleukin-1beta induced Fos expression in CeA, BNST and VLM neurons and that neurons of the NTS and VLM may serve to trigger or at least influence changes in parabrachial nucleus activity that follows systemic interleukin-1beta administration
Martin et al., Arthritis Rheum 2004 (Anoxia) : IL-1beta induced DNA binding of NF-kappaB and AP-1 was significantly higher in hypoxic and reoxygenated cultures than in normoxia
Baker et al., Am J Physiol Regul Integr Comp Physiol 2005 : Interleukin 1beta enhances non-rapid eye movement sleep and increases c-Fos protein expression in the median preoptic nucleus of the hypothalamus
Jana et al., Free Radic Biol Med 2005 : Although IL-1beta and IFN-gamma alone induced the activation of AP-1 , the combination of these two cytokines ( IL-IF ) markedly inhibited the activation of AP-1 ... Consistently, JNK-I, a specific inhibitor of JNK, inhibited IL-1beta mediated activation of AP-1 and expression of iNOS
Migita et al., Immunol Lett 2005 (Arthritis, Rheumatoid) : FK506 also prevented IL-1beta stimulated JNK activation and transcriptional activation of AP-1 in these cells
Nadjar et al., Biol Psychiatry 2005 (Body Weight) : Inactivation of the cerebral NFkappaB pathway inhibits interleukin-1beta induced sickness behavior and c-Fos expression in various brain nuclei ... NFkappaB pathway inactivation significantly blocked the behavioral effects of intraperitoneally administered IL-1beta in the form of social withdrawal and decreased food intake, and dramatically reduced IL-1beta induced c-Fos expression in various brain regions as paraventricular nucleus, supraoptic nucleus, and lateral part of the central amygdala
Martin et al., Osteoarthritis Cartilage 2005 : IL-1beta enhanced both AP-1 and NF-kappaB binding, whereas H ( 2 ) O ( 2 ) only activated AP-1 ... The different regulation of NF-kappaB and AP-1 by H ( 2 ) O ( 2 ) and IL-1beta underlines the distinct roles played by the two transcription factors in the regulation of gene expression
Hwang et al., J Biol Chem 2005 : Consistent with its ability to induce phosphorylation of c-Jun, IL-1beta caused transient activation of AP-1 , which is necessary for IL-1beta induced dedifferentiation
Tonosaki et al., Neuroendocrinology 2005 (Hyperalgesia) : alpha-Melanophore stimulating hormone ( alpha-MSH ) antagonizes interleukin-1beta induced hyperalgesia and Fos expression in the paraventricular and arcuate nucleus of the rat
Yamazaki et al., In Vitro Cell Dev Biol Anim 2005 (Sarcoma, Synovial) : Both NF-kappaB and AP-1 deoxyribonucleic acid binding activities were detectable in SW982 cells by EMSA, and they were induced by interleukin-1beta treatment
Shah et al., Int J Cancer 2006 (Colonic Neoplasms) : Ursodeoxycholic acid inhibits interleukin 1 beta [ corrected ] and deoxycholic acid induced activation of NF-kappaB and AP-1 in human colon cancer cells
Masamune et al., J Cell Biochem 2006 : Curcumin inhibited interleukin-1beta- and TNF-alpha induced activation of activator protein-1 (AP-1) and mitogen activated protein ( MAP ) kinases ( ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase ), but not of nuclear factor-kappaB (NF-kappaB)
Wehkamp et al., J Invest Dermatol 2006 : Pseudomonas aeruginosa- and IL-1beta mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1
Terzidou et al., J Clin Endocrinol Metab 2006 : OTR promoter contains putative transcription factor binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP), and nuclear factor-kappaB (NF-kappaB), which may be activated by IL-1beta , whose concentrations increase with labor
Domagala et al., Biorheology 2006 : Inhibition of interleukin-1beta induced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1 : potential mechanism for Diacerein effects in osteoarthritis
Mohan et al., Endocrinology 2007 : In contrast, IL-1beta increased both AP-1 and NF-kappaB DNA binding at 1 h only
Li et al., Neuroreport 2007 (Hyperalgesia) : This study investigated the role of interleukin-1beta in the expression of Fos , a marker of neuronal activation, and hyperalgesia caused by injecting complete Freund 's adjuvant into one hind paw of the rat
Hammaker et al., Arthritis Res Ther 2007 (Arthritis, Rheumatoid) : In addition, MKK4 and MKK7 kinase activity were significantly decreased in TAK1 deficient FLSs. Electrophoretic mobility shift assays demonstrated a significant decrease in IL-1beta induced AP-1 activation due to TAK1 knockdown
Legendre et al., Clin Exp Rheumatol 2007 : The drug reduced IL-1Beta induced NF-kappaB and AP-1 DNA binding, as well as the phosphorylation of ERK and JNK
Jomphe et al., Basic Clin Pharmacol Toxicol 2008 : Chondroitin sulfate reduced IL-1beta induced NF-kappaB nuclear translocation, but not AP-1 translocation, it decreased IL-1beta induced phosphorylation of Erk1/2 and abrogated p38MAPK phosphorylation, but did not prevent IL-1beta induced increase in nitrite
Liang et al., Mol Hum Reprod 2008 : Since IL-1beta activates NFkappaB, AP-1 and C/EBP, we over expressed these transcription factors alone and in combination and found that only NFkappaB alone increased FP mRNA expression
Lin et al., Rheumatol Int 2008 (Chondrosarcoma...) : A slightly synergistic effect on the activation of AP-1 induced by IL-1beta was shown in the presence of GLN
Brechter et al., Bone 2008 : EMSA showed that IL-1beta and TNF-alpha activated NF-kappaB and AP-1 in MG-63 cells
Bianchi et al., Neurobiol Aging 2010 (Encephalitis...) : We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2, IL-1beta and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1
Noh et al., Rheumatology (Oxford) 2009 (Arthritis, Rheumatoid...) : Moreover, cordycepin significantly inhibited IL-1beta induced p38/JNK and AP-1 activation, but not extracellular signal regulated kinase ( ERK ) and NF-kappaB activation
Sabolek et al., Stem Cells 2009 (MAP Kinase Signaling System) : Surprisingly, IL-1beta did not activate the NF-kappaB pathway or the transcription factor activating protein 1 (AP-1) , but inhibition of nuclear translocation of NF-kappaB by SN50 facilitated IL-1beta induced Nurr1 expression and dopaminergic differentiation of mdNPCs
Wang et al., Cytokine 2009 (Acute Lung Injury) : ZD 7155 also reduced the mRNA expression of TNF-alpha and IL-1 beta , inhibited the activation of NF-kappaB and AP-1 , and improved lung histopathology
Fan et al., J Biol Chem 2010 : Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta induced IKK/NF-kappaB and JNK/AP-1 activation
Yang et al., J Cell Physiol 2010 (Arthritis, Rheumatoid) : IL-1beta induced ICAM-1 expression, extracellular signal regulated kinase ( ERK ) and c-Jun-N-terminal kinase (JNK) phosphorylation, AP-1 activation , and nuclear factor-kappaB (NF-kappaB) p65 translocation were attenuated by the inhibitors of MEK1/2 ( U0126 ), JNK ( SP600125 ), AP-1 ( tanshinone IIA ), and NF-kappaB ( helenalin ) or transfection with respective short hairpin RNA plasmids ... IL-1beta stimulated AP-1 activation was blocked by U0126 or SP600125, revealing that ERK and JNK linked to AP-1 on these responses
Choi et al., Food Chem Toxicol 2010 (Sarcoma) : Moreover, IL-1beta induced activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) activation were inhibited by luteolin
Chang et al., Adv Exp Med Biol 1995 : Chronic treatment with morphine and ethanol, but not cocaine, attenuates IL-1 beta activation of FOS expression in the rat hypothalamic paraventricular nucleus ... In this study, we compared the effects of morphine, ethanol and cocaine on IL-1 beta induction of FOS-IR in the rat hypothalamus ... Chronic treatment with morphine desensitized FOS responsiveness to morphine and IL-1 beta in the PVN since FOS-IR was no longer induced by IL-1 beta or morphine in the PVN after this treatment
Quentmeier et al., Leuk Res 1994 : Alternatively, these data support the notion that neither AP-1 nor the c-myc protein are involved in the MDHM induced increase in IL-1 beta , IL-6 or TNF alpha mRNA levels
Serkkola et al., Eur J Biochem 1993 : We have now examined the role of AP-1 in the regulation of the IL-1 beta gene expression by PKC and cAMP in THP-1 cells
Hattori et al., Am J Physiol 1993 (Acute-Phase Reaction...) : In addition, IL-6, tumor necrosis factor-alpha, and IL-1 beta , cytokine regulators of the acute phase response, stimulated expression of an AP-1 responsive reporter gene introduced by DNA mediated transfection into adult rat hepatocytes in primary culture
Lieb et al., J Neurochem 1996 (Astrocytoma) : Activation of the transcription factor nuclear factor-kappa B by IL-1 beta involved ROIs, whereas the IL-1 beta induced activation of the transcription factor AP-1 was mediated via protein kinase C
Swiergiel et al., Brain Res Bull 1996 : Intraperitoneally injected IL-1 beta increased Fos in several brain regions, but most obviously in the hypothalamic paraventricular nucleus ( PVN )
Callahan et al., J Neuroimmunol 1997 : IL-1beta induced Fos expression in corticotrophin releasing factor (CRF) neurons of paraventricular nucleus ( PVN ) of the hypothalamus, and anterior pituitary gland