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DDIT3 — EPHB2

Text-mined interactions from Literome

Ou et al., Eur J Pharmacol 2007 (Carcinoma, Renal Cell...) : Selective inhibitors of ERK , p38 MAPK, and JNK suppressed the induction of GRP78, CHOP , and PPAR-beta, attenuated indomethacin induced cytotoxicity and reduced increased caspase activity
Lawrence et al., Proc Natl Acad Sci U S A 2007 (MAP Kinase Signaling System) : Both induction and repression of CHOP are dependent on the MAPKs ERK1 and ERK2
Lawrence et al., Acta Physiol (Oxf) 2008 : CHOP gene expression, especially that regulated by nutrients, is also ERK1/2 dependent in beta cells, These studies support the hypothesis that the genes regulated by ERK1/2 and the mechanisms employed are key to maintaining normal beta cell function