Karmakar et al., J Biol Chem 2002
(Werner Syndrome) :
We find that although DNA-PKcs alone does not affect the WRN exonuclease activity, the additional presence of Ku mediates a marked inhibition of it ... The inhibition of WRN exonuclease by DNA-PKcs requires the kinase activity of DNA-PKcs Kusumoto-Matsuo et al., Aging 2010
(Werner Syndrome) :
The results show that DNA-PKcs selectively stimulates WRN helicase but not WRN exonuclease in vitro, affecting that WRN helicase unwinds and promotes the release of the full-length invading strand of a telomere D-loop model substrate