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EGF — SMAD5
Text-mined interactions from Literome
Diamond et al., J Cell Sci 2008
(Carcinoma, Squamous Cell...) :
Mechanistically,
EGF enhanced Smad phosphorylation in the linker region, and
attenuated TGFbeta1 mediated phosphorylation of
Smad at the C-terminus, localization of Smad to the nucleus as well as Smad-driven promoter activity exclusively in oral keratinocytes but not in OSCC cells ... The
effect of
EGF on TGFbeta1 mediated
Smad-driven promoter activity and N-cadherin expression was reversed when activation of ERK1/2 was blocked
de Caestecker et al., Genes Dev 1998
:
We demonstrate here that HGF and
EGF , which signal through RTKs, can also mediate SMAD dependent reporter gene activation and
induce rapid phosphorylation of endogenous
SMAD proteins by kinase ( s ) downstream of MEK1