Gene interactions and pathways from curated databases and text-mining

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FGF2 — PCNA

Text-mined interactions from Literome

Weng et al., Zhonghua Yan Ke Za Zhi 2002 : To observe the effect of the expression of proliferating cell nuclear antigen ( PCNA ) induced by basic fibroblast growth factor (bFGF) on the proliferation of bovine lens epithelial cells ( BLECs )
Frederick et al., Mol Cell Neurosci 2004 : IGF-I and FGF-2 coordinately enhance cyclin D1 and cyclin E-cdk2 association and activity to promote G1 progression in oligodendrocyte progenitor cells ... IGF-I enhanced FGF-2 induction of cyclin D1, activation of G ( 1 ) cyclin-cyclin dependent kinase (cdk) complexes, and hyperphosphorylation of retinoblastoma protein ( pRb )
Neary et al., Purinergic Signal 2005 : Because FGF2 and P2 purinergic receptors are coupled to extracellular signal regulated protein kinase ( ERK ), a key member of a signaling cascade that regulates proliferation, we also investigated the role of ERK in regulating cyclin expression induced by FGF2 and ATP ... P2 receptor agonist studies revealed that UTP enhanced FGF2 induced cyclin expression and mitogenesis whereas 2-methylthioADP was ineffective
Katayama et al., Int J Oncol 2010 (Prostatic Neoplasms) : Overall, bicalutamide inhibits the cyclin A expression possibly by inhibiting FGF-8 mRNA expression and FGF-8 protein secretion but not by inhibiting FGF receptor ( FGFR ) signalling in androgen dependent cell lines, and by other mechanisms in androgen independent cell lines
Kolupaeva et al., Cell cycle (Georgetown, Tex.) 2012 : In cells overexpressing cyclin D1/CDK4, FGF induced downregulation of cyclin E/CDK2 activity was absent
Bravo et al., EMBO J 1984 : In addition, partially purified PDGF and FGF also induce cyclin and DNA synthesis in a coordinate way
Rao et al., J Biol Chem 1995 : Positive and negative regulation of D-type cyclin expression in skeletal myoblasts by basic fibroblast growth factor and transforming growth factor beta ... We investigated the effects of bFGF and TGF beta on D-type cyclin expression in skeletal myoblasts
Wang et al., Cancer Res 1997 : bFGF induced an increase in cyclin D1, cyclin E, and cyclin dependent kinase 4 (cdk4) protein levels in a bFGF dose dependent manner ... These experiments demonstrate that stimulation of MCF-7 cells with bFGF , although resulting in up-regulation of G1 proteins responsible for mitogenic events, also induces a concomitant decrease in cyclin A levels and an increase in p21 ( WAF1/CIP1 ) mRNA and protein and results in inactivation of cdk2, dephosphorylation of Rb, and a segregation of PCNA to the G1 cyclin complexes
Murakami-Mori et al., J Immunol 1998 (Acquired Immunodeficiency Syndrome...) : Thus, FGF actions are essential for cyclin E-CDK2 activity and S phase entry ... Endogenous basic fibroblast growth factor is essential for cyclin E-CDK2 activity in multiple external cytokine induced proliferation of AIDS associated Kaposi 's sarcoma cells : dual control of AIDS associated Kaposi 's sarcoma cell growth and cyclin E-CDK2 activity by endogenous and external signals