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CDH1 — MMP9
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Mei et al., Carcinogenesis 2002
:
The sum effect of MMP inhibitors demonstrated that NO-induced activation of
MMP may
cause the degradation of
E-cadherin and the subsequent dissociation of beta-catenin, thereby contributing to the cytosolic accumulation of beta-catenin and nuclear formation of beta-catenin/LEF-1 complex
Nawrocki-Raby et al., Am J Pathol 2003
(Bronchial Neoplasms...) :
E-Cadherin mediates
MMP down-regulation in highly invasive bronchial tumor cells
Wang et al., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2004
(Lymphatic Metastasis...) :
In the group of nasopharyngeal carcinoma with distant metastasis, the expression of
E-cadherin and nm23H1 also increased and the expression of CD44H,
MMP-3 and VEGF all
increased
Cowden Dahl et al., Cancer Res 2008
(Neoplasm Invasiveness...) :
Stable overexpression of
MMP-9 led to a loss of
E-cadherin and junctional integrity, and promoted a migratory and invasive phenotype ... Thus, elevated
MMP-9 protein expression is
sufficient for junctional disruption and loss of
E-cadherin in these cells
Zhao et al., Cancer Lett 2013
(Neovascularization, Pathologic...) :
EA also reversed epithelial to mesenchymal transition by up-regulating
E-cadherin and
inhibiting the expression of Snail,
MMP-2 and MMP-9