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CRK — CXCR4

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CRK → CXCR4 (increases, CRK Activity) Wang et al., Blood 2000
  Evidence: We observed that several other focal adhesion components, including focal adhesion kinase (FAK) and the adaptor molecules Crk and Crk-L, are phosphorylated on SDF-1alpha stimulation.

Text-mined interactions from Literome

Trushin et al., J Immunol 2007 : Because ligation of the CD4 receptor alone or the CXCR4 receptor alone causes p38 activation and apoptosis, we used the soluble inhibitors, soluble CD4 ( sCD4 ) or AMD3100, to delineate the role of CD4 and CXCR4 receptors, respectively, in gp120 induced p38 activation and death
Shepherd et al., J Neurosci 2012 : However, prolonged SDF-1a treatment leads to CXCR4 mediated activation of p38 mitogen activated protein kinase, resulting in phosphorylation of Kv2.1 at S800 and enhanced surface trafficking of the channel protein, resulting in increased I ( DR ) /Kv2.1 current density