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CCND1 — PTHLH

Text-mined interactions from Literome

Beier et al., Mol Endocrinol 2002 (Exostoses, Multiple Hereditary) : Here we demonstrate that JMC mutations of the PTH/PTHrP receptor induce activation of the cyclin D1 and cyclin A promoters in primary mouse chondrocytes and rat chondrosarcoma cells
Datta et al., J Bone Miner Res 2005 (MAP Kinase Signaling System) : PTHrP inhibited cyclin D1 protein expression 7-fold in a dose- and time dependent manner and increased the level of p16 protein in differentiated osteoblasts ... Additionally, PTHrP reduced cyclin D1-CDK4/CDK6 and CDK1 kinase activities ... H-89, a PKA inhibitor, did not alter the effect of PTHrP on cyclin D1 , suggesting a PKA independent mechanism ... PTHrP upregulates JunB and reduces cyclin D1 expression while inducing G1 cell cycle arrest in differentiated osteoblasts
Datta et al., J Bone Miner Res 2007 : PTHrP induced a proliferative cyclin D1 activation in low-density osteoblastic cells ... These data indicate that PTH and PTHrP induce cyclin D1 expression in early osteoblastic cells and their action is developmental stage specific