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PPARA — SAA1
Text-mined interactions from Literome
Gervois et al., J Biol Chem 2004
(Acute-Phase Reaction) :
PPARalpha prevents the IL-6 induced expression of the positive APR genes fibrinogen-alpha, -beta, -gamma, haptoglobulin, and
serum amyloid A and the IL-6 induced suppression of the negative APR gene, major urinary protein
Faty et al., PloS one 2012
(Inflammation) :
At the molecular level,
SAA represses
PPAR?2 , C/EBPa and SREBP-1c gene expression, three transcription factors involved in adipocyte differentiation or lipid synthesis