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HSP90AA1 — SETD2
Text-mined interactions from Literome
Minet et al., FEBS Lett 1999
(Anoxia) :
Hypoxia induced activation of
HIF-1 :
role of
HIF-1alpha-Hsp90 interaction ... This work was aimed to investigate the putative
role of
Hsp90 in
HIF-1 activation by hypoxia ... At last, we showed that
Hsp90 activity is
essential for
HIF-1 activation in hypoxia since it is inhibited in the presence of geldanamycin
Braliou et al., Biochem Biophys Res Commun 2006
:
The use of this system for the identification and characterization of HIF-1 effectors was first validated by showing that two chemical
Hsp90 inhibitors, geldanamycin and radicicol,
impaired the activity of
HIF-1 in yeast
Lee et al., Int J Cancer 2012
(Neoplasms...) :
Thus, the inhibition of
HIF-1a activity by hemin might
result from its interaction with
HSP90
Sahu et al., Mol Biol Cell 2012
(Neoplasm Invasiveness...) :
Our finding that
HIF-1a regulates secretion of
heat shock protein-90a (Hsp90a) for cell migration raises the exciting possibility that targeting the secreted Hsp90a from HIF-1a positive tumors has a better clinical outlook
Schilling et al., PloS one 2012
(Anoxia...) :
Herein, we describe the
effects of the novel
Hsp90 inhibitor NVP-AUY922 and 17-allylamino-17-demethoxygeldanamycin ( 17-AAG ), as a control, on
HIF-1a levels and radiosensitivity of lung carcinoma cells under normoxic and hypoxic conditions