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IL4 — NFATC2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/PPARG complex (NFATC1_NFATC2_NFATC3-PPARG) → IL4 (IL4) (transcription, inhibits) Chung et al., Mol Pharmacol 2003
  Evidence: reporter gene
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1 (NFATC2) → IL4 (IL4) (transcription, activates) Agarwal et al., Immunity 2000*, Avni et al., Nat Immunol 2002*
  Evidence: reporter gene, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Innatedb Interaction: Complex of IL4-NFATC2-NFATC2 (unknown, -) Yao et al., Biochem Biophys Res Commun 2012*

Text-mined interactions from Literome

Diehl et al., J Exp Med 2002 : The ability of IL-6 to promote Th2 differentiation is impaired in CD4+ T cells that lack NFATc2, demonstrating that NFATc2 is required for regulation of IL-4 gene expression by IL-6
Chargé et al., Cell 2003 (Hypertrophy) : The authors demonstrate that NFATc2 signaling in newly formed myotubes induces IL-4 expression and secretion which promotes myoblast fusion with pre existing myotubes
Yang et al., J Biol Chem 2006 (Carcinoma, Hepatocellular...) : We report that interleukin-1 or tumor necrosis factor-alpha increases expression of and activates NFATc2