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CCR4 — IL4
Text-mined interactions from Literome
Jinquan et al., Immunology 2000
(Inflammation) :
CXC
chemokine receptor 4 expression and stromal cell derived factor-1alpha induced chemotaxis in CD4+ T lymphocytes are
regulated by
interleukin-4 and interleukin-10
Athanassakis et al., Hum Immunol 2000
:
Furthermore, in the
presence of
IL-4 ,
CCR3 expression declines from 2 to 8 h of culture to increase again at 24 h, where 50 % of the cell population is expressing the receptors
Kim et al., J Immunol 2003
:
IL-4 enhances the generation of
CCR4 ( + ) and CRTH2 ( + ) T cells, and suppresses the generation of CXCR3 ( + ) T cells and CCR7 ( - ) T cells, while IL-12 suppresses the level of CCR4 in responding T cells
Nureki et al., Clin Immunol 2005
(Pulmonary Eosinophilia) :
Interleukin-4 enhanced
CCR4 ligand production
Jiang et al., Chin Med J (Engl) 2009
(Embryo Loss) :
Expression of chemokine receptors CCR3,
CCR5 and CXCR3 on CD4 ( + ) T cells in CBA/JxDBA/2 mouse model, selectively
induced by
IL-4 and IL-10, regulates the embryo resorption rate ... This study aimed to observe whether
IL-4 and IL-10 may
regulate the expression of chemokine receptors CCR3,
CCR5 and CXCR3 on CD4 ( + ) T cells in CBA/JxDBA/2 mouse model and to explore the role of CCR3, CCR5, CXCR3 in immune tolerance in pregnancy ... The pregnancy immune tolerance may be
induced through selective induction of CCR3,
CCR5 and CXCR3 expressions by
IL-4 together with IL-10
Wang et al., Thorax 2013
(Asthma...) :
However,
CCR8 inhibition
had no significant effect on allergen induced BAL eosinophilia and the induction of the Th2 cytokines
IL-4 , IL-5, IL-13 and mucus levels in BAL
D'Ambrosio et al., J Immunol 1998
:
IL-4 is not
required for this activation induced up-regulation of
CCR4 and CCR8