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NCAM1 — NEUROD4
Text-mined interactions from Literome
Ditlevsen et al., J Neurochem 2003
:
The role of phosphatidylinositol 3-kinase in
neural cell adhesion molecule mediated
neuronal differentiation and survival
Berezin et al., J Mol Neurosci 2004
(Neurodegenerative Diseases) :
The
neural cell adhesion molecule ( NCAM ) plays an important role in
neuronal differentiation and synaptic plasticity, making it an attractive target for the development of drugs for the treatment of neurodegenerative disorders
Kulahin et al., J Neurochem 2005
:
These observations indicate that
neuronal differentiation induced by homophilic
NCAM interaction is modulated by interactions with heparan/chondroitin sulfates
Kiryushko et al., Mol Biol Cell 2006
:
Thus, unanticipated mechanisms of Ca2+ homeostasis are shown to be activated by
NCAM and to
contribute to
neuronal differentiation
Kim et al., Exp Mol Med 2006
:
Therefore, we investigated whether the MEK1 plays a critical role in the
NCAM induced
neuronal differentiation of hippocampal neural progenitor cells ( NPCs ) ... The expression of DN MEK1 inhibited neuronal phenotype acquisition and soluble NCAM rescued the defect in the neuronal phenotype acquisition in DN-MEK1 transfected cells, suggesting that
NCAM might
contribute to the
neuronal differentiation via distinct, parallel pathways including the MEK pathway
Ditlevsen et al., J Neurosci Res 2008
:
Stimulation of
NCAM by homophilic interactions
induces neuronal differentiation through activation of a number of signaling molecules, including the fibroblast growth factor receptor, non-receptor kinases Fyn and focal adhesion kinase, growth associated protein-43, the mitogen activated protein kinase pathway, intracellular Ca ( 2+ ), and protein kinases A, C, and G