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PDGFB — STAT3
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
PDGFB
→
STAT3
(indirect_complex)
Vignais et al., Mol Cell Biol 1996, Valgeirsdóttir et al., Oncogene 1998, Heldin et al., Biochim Biophys Acta 1998
-
Reactome Reaction:
PDGFB
→
STAT3
(reaction)
Vignais et al., Mol Cell Biol 1996, Valgeirsdóttir et al., Oncogene 1998, Heldin et al., Biochim Biophys Acta 1998
Text-mined interactions from Literome
Neeli et al., J Biol Chem 2004
:
PDGF-BB stimulated tyrosine phosphorylation of Jak-2 and
STAT-3 in a time dependent manner in VSMCs ... In addition, AG490 and Jak-2KEpRK5, a selective pharmacological inhibitor and a dominant negative mutant, respectively, of Jak-2, attenuated
PDGF-BB induced
STAT-3 tyrosine phosphorylation and its DNA binding and reporter gene activities ...
PDGF-BB induced the expression of cPLA(2) in a
Jak-2/STAT-3 dependent manner, and pharmacological inhibitors of cPLA(2) prevented PDGFBB induced VSMC motility
Wu et al., Pharmacol Res 2009
(MAP Kinase Signaling System) :
FBS- and PDGF-BB stimulated intracellular Ras, MEK1/2, ERK1/2, proliferative cell nuclear antigen ( PCNA ), and Akt activations were significantly inhibited by lercanidipine ; however, lercanidipine did not affect FBS- and
PDGF-BB induced
STAT3 phosphorylation
Lennartsson et al., J Biol Chem 2013
(Cell Transformation, Neoplastic...) :
In cells in which Fer was down-regulated using siRNA,
PDGF-BB was unable to
induce phosphorylation of
STAT3 , whereas phosphorylations of STAT5, ERK1/2, and Akt were unaffected ...
PDGF-BB induced activation of
STAT3 occurred also in cells expressing kinase-dead Fer, suggesting a kinase independent adaptor role of Fer ... Our data suggest a critical role of Fer in
PDGF-BB induced
STAT3 activation and cell transformation
Garcia et al., Cell Growth Differ 1997
(Breast Neoplasms...) :
In addition,
Stat3 activation is
induced by another nonreceptor tyrosine kinase, v-Fps ; by polyoma virus middle T antigen, which activates Src family kinases ; and by
v-Sis , which acts as a ligand for the platelet derived growth factor receptor