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IL1B — VCAM1
Text-mined interactions from Literome
Croft et al., Am J Pathol 1999
(Arthritis, Rheumatoid) :
Fibroblast-like synoviocytes rapidly up-regulate
VCAM-1 expression in
response to
IL-1beta and TNF-alpha, but also to IL-4
Wright et al., J Cell Physiol 1999
:
TNF-alpha and
interleukin-1beta (IL-1beta) stimulated cell surface ICAM-1 expression, but not
VCAM-1 expression, in human aortic smooth muscle cells ( HASMCs )
Wu et al., Atherosclerosis 1999
:
Enrichment of HAEC with the same doses of vitamin E suppressed
IL-1beta stimulated expression of intercellular adhesion molecule-1 ( ICAM-1 ),
vascular cell adhesion molecule-1 ( VCAM-1 ), and endothelial leukocyte adhesion molecule-1 ( E-selectin )
Spoelstra et al., Eur Respir J 1999
:
IL-1beta ( optimal concentration ( OC ) 1 U x mL(-1) ) and TNFalpha ( OC 100 U x mL(-1) ) both
increased ICAM-1 and
VCAM-1 expression
Orozco et al., Infect Immun 2000
(Inflammation) :
Expression of
VCAM-1 was
mediated not only by TNF-alpha but also by IL-1alpha and
IL-1beta , all of which were synthesized by endothelial cells in response to C. albicans
Yoshida et al., Aliment Pharmacol Ther 2000
(Helicobacter Infections...) :
The expression of CD11b and CD18 on neutrophils and neutrophil dependent adhesion to endothelial cells elicited by HPE were inhibited by lansoprazole and omeprazole at clinical relevant doses, and the expression of ICAM-1 and
VCAM-1 on endothelial cells and endothelial dependent neutrophil adherence
induced by
IL-1beta were also inhibited by lansoprazole and omeprazole at similar doses
Umetani et al., Biochem Biophys Res Commun 2000
:
K-7174 inhibited the expression of
vascular cell adhesion molecule-1 ( VCAM-1 )
induced by either tumor necrosis factor alpha or
interleukin-1beta , without affecting the induction of intercellular adhesion molecule-1 or E-selectin
Rood et al., Eur J Clin Invest 2000
:
Upon
stimulation with
IL-1beta the expression of E-selectin,
VCAM-1 and ICAM-1 ( CD54 ) was upregulated ... The expression of E-selectin and
VCAM-1 , which are not constitutively expressed on the cell lines, can be induced by
stimulation of the endothelial cells with
IL-1beta
Tummala et al., J Mol Cell Cardiol 2000
:
DPI also inhibited TNF and LPS induced VCAM-1 and ICAM-1 cell surface expression and TNF- alpha, LPS, or
IL-1 beta induced
VCAM-1 and ICAM-1 mRNA accumulation
Harcourt et al., J Interferon Cytokine Res 2000
:
Much higher levels of mRNA for interleukin-6 (IL-6), 2',5'-oligoadenylate synthetase ( 2',5'-OAS ), protein kinase ( PKR ), and interferon (IFN) regulatory factor-1 ( IRF-1 ) result from incubation with dsRNA than with IL-1beta, tumor necrosis factor-alpha (TNF-alpha), or IFN-alpha, whereas the differences in
vascular cell adhesion molecule-1 ( VCAM-1 ), intercellular adhesion molecule-1 ( ICAM-1 ), and E-selectin mRNA expression in
response to dsRNA,
IL-1beta , and TNF-alpha are relatively minor
Sharp et al., Inflammation 2001
(Inflammation) :
ICAM-1,
VCAM-1 , and E-selectin expression were all
stimulated by both
IL-1beta and TNF-alpha in the 24 h assays
Liu et al., Zhonghua Yi Xue Za Zhi 2001
:
( 3 ) The expression rate of VCAM-1 in VECs increased significantly after interleukin-1 beta acted on the cells ( 17.5 % +/- 1.5 % ). 17-beta estradiol at the contents of 3 x 10 ( -8 ) -10 ( -6 ) mol/L all counteracted the increase in expression rate of
VCAM-1 induced by
interleukin-1 beta ( 15.4 % +/- 1.42 %, 12.4 % +/- 0.34 %, 8.7 % +/- 0.27 %, P < 0.01 )
Cattaruzza et al., J Biol Chem 2002
(Inflammation) :
Antisense oligonucleotide suppression of zfm1 protein synthesis mimicked the stimulatory
effects of
IL-1 beta and TNF alpha on SMC proliferation and expression of the chemokine MCP-1 and the
vascular cell adhesion molecule-1
Spoelstra et al., Thorax 2002
:
Formoterol exerted an additive effect on the inhibition of
IL-1beta stimulated ICAM-1 and
VCAM-1 upregulation and GM-CSF production by budesonide in concentrations of 10 ( -9 ) M and above ( p < 0.05 )
Lee et al., Nephron 2002
:
Furthermore, SIN-1 and NP inhibited the
VCAM-1 mRNA expression
induced by
interleukin-1beta or lipopolysaccharide as well
Piercy et al., J Surg Res 2002
:
Effects of estrogen, progesterone, and combination exposure on
interleukin-1 beta induced expression of
VCAM-1 , ICAM-1, PECAM, and E-selectin by human female iliac artery endothelial cells ... Pretreatment with estrogen or progesterone alone decreased
IL-1 beta stimulated
VCAM-1 and ICAM-1 expression, but not to statistically significant levels
Raeburn et al., Am J Physiol Heart Circ Physiol 2002
:
Because IL-18 is a proinflammatory cytokine known to mediate the production of TNF-alpha and
IL-1beta and to
induce the expression of intercellular adhesion molecule-1 ( ICAM-1 ) and
vascular cell adhesion molecule-1 ( VCAM-1 ), we hypothesized that neutralization of IL-18 would attenuate lipopolysaccharide (LPS) induced cardiac dysfunction
Tatsumi et al., Maturitas 2002
(Arteriosclerosis) :
In all preparations of HUVECs used in this study, RT-PCR confirmed mRNA expression of both isoforms of PR, PR-A and PR-B, as well as AR. Addition of progesterone ( 10 ( -10 ) -10 ( -7 ) M ) or dienogest ( DNG ) ( 10 ( -10 ) -10 ( -8 ) M ) did not affect
IL-1beta stimulated ICAM-1 or
VCAM-1 expression
Jiang et al., J Biol Chem 2004
(Inflammation) :
The present study examined the effect of angiotensin II on
interleukin-1beta induced NF-kappaB activation and the subsequent expression of inducible NO synthase (iNOS) and
vascular cell adhesion molecule-1 ( VCAM-1 ) in cultured rat vascular smooth muscle cells
Ludwig et al., Biochem Biophys Res Commun 2004
:
EGCG also inhibited the
IL-1beta induced induction of
VCAM-1 expression
Liu et al., Atherosclerosis 2004
(Arteriosclerosis) :
Pre-incubation of HAEC with AEM at 20 and 40 microg/ml, but not at 4 microg/ml, for 24h significantly suppressed
IL-1beta stimulated expressions of intracellular adhesion molecule-1 ( ICAM-1 ),
vascular cell adhesion molecule-1 ( VCAM-1 ), and E-selectin and the secretion of proinflammatory cytokines IL-6, chemokines IL-8 and monocyte chemoattractant protein (MCP)-1
Wang et al., Am J Physiol Lung Cell Mol Physiol 2005
:
Involvement of p42/p44 MAPK, p38 MAPK, JNK, and NF-kappaB in
IL-1beta induced
VCAM-1 expression in human tracheal smooth muscle cells ... Here, the roles of mitogen activated protein kinases ( MAPKs ) and nuclear factor-kappaB (NF-kappaB) pathways for
IL-1beta induced
vascular cell adhesion molecule (VCAM)-1 expression were investigated in human tracheal smooth muscle cells ( HTSMC ) ...
IL-1beta induced expression of
VCAM-1 protein and mRNA in a time dependent manner, which was significantly inhibited by inhibitors of MEK1/2 ( U0126 and PD-98059 ), p38 ( SB-202190 ), and c-Jun NH ( 2 ) -terminal kinase ( JNK ; SP-600125 ) ...
IL-1beta induced
VCAM-1 expression was significantly blocked by the specific NF-kappaB inhibitors helenalin and pyrrolidine dithiocarbamate ... Together, these results suggest that in HTSMC, activation of p42/p44 MAPK, p38, JNK, and NF-kappaB pathways is essential for
IL-1beta induced
VCAM-1 gene expression
Cartwright et al., Exp Cell Res 2005
:
Trophoblast interactions with endothelial cells are increased by
interleukin-1beta and tumour necrosis factor alpha and
involve vascular cell adhesion molecule-1 and alpha4beta1
Honda et al., Oral Microbiol Immunol 2005
(Coronary Artery Disease...) :
Although TNF-alpha and
IL-1beta , at concentrations a little higher than those in sera of periodontitis patients,
up-regulated the expression of intercellular adhesion molecule-1 and
vascular cell adhesion molecule-1 , P. gingivalis antigens had only a slight stimulatory effect
Lee et al., Nephrol Dial Transplant 2005
(Disease Models, Animal...) :
In cultured tubular epithelial cells, rosiglitazone significantly decreased the expression of ICAM-1 and
VCAM-1 induced by TNF-alpha or
IL-1beta , inhibited the degradation of inhibitor kappaBalpha ( IkappaBalpha ) and blocked the activation of the p65 subunit of nuclear factor (NF)-kappaB
Alique et al., Int Z Vitam Ernahrungsforsch Beih 2005
:
All-trans-retinoic acid ( tRA ) modulates in human mesangial cells ( MC ) antioxidant defenses, the expression of
interleukin-1beta induced
vascular cell-adhesion molecule-1 ( VCAM-1 ), cyclooxygenase-2 (COX-2), and the retinoic acid-receptor-beta (RAR-beta)
Chen et al., Invest Ophthalmol Vis Sci 2005
:
Stimulation of hRVECs with VEGF ( 165 ), TNFalpha, or
IL-1beta for 6 to 24 hours
caused significant induction of intracellular adhesion molecule (ICAM)-1 and
vascular cell adhesion molecule (VCAM)-1 expression ...
IL-1beta , TNFalpha, and VEGF ( 165 )
induced nuclear translocation and binding of p65 and p50 NF-kappaB isoforms to the
VCAM-1 promoter
Yu et al., Br J Nutr 2007
:
In the present study, we investigated the effects of EA on the formation of intracellular reactive oxygen species, the translocation of NFkappaB and expression of
vascular cell adhesion molecule-1 ( VCAM-1 ), intercellular adhesion molecule-1 and endothelial leucocyte adhesion molecule ( E-selectin )
induced by
IL-1beta in human umbilical vein endothelial cells ( HUVEC )
Jagavelu et al., Circ Res 2007
(Atherosclerosis...) :
Furthermore, silencing of MK2 in endothelial cells by siRNA reduced the
IL-1beta induced expression of
VCAM-1 and MCP-1
Han et al., J Agric Food Chem 2007
:
Compounds 1 and 2 inhibited tumor necrosis factor (TNF)-alpha induced up-regulation of
vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ), which also prevented adhesion of monocytes to HUVECs, and slightly
suppressed the mRNA expression of the inflammation associated gene
interleukin-1beta (IL-1beta)
Bayat et al., Arterioscler Thromb Vasc Biol 2008
:
Activation of thromboxane receptor upregulates interleukin
(IL)-1beta induced
VCAM-1 expression through JNK signaling ... This study examined how activation of TPr modulates
IL-1beta induced
vascular cell adhesion molecule (VCAM)-1 expression in aortic vascular smooth muscle cells ( VSMCs ) ... This study demonstrates that activation of TPr upregulates
IL-1beta induced
VCAM-1 expression by enhancing the activation of JNK pathway that leads to enhanced AP-1 activation
Gustavsson et al., Retina 2008
(Diabetes Mellitus, Experimental...) :
Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ),
IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and IL-6 ( P = 0.012 ), and diabetes
induced increased expression of caspase-1 ( P < or= 0.046 ),
VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ), IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Hastings et al., Arterioscler Thromb Vasc Biol 2009
(Atherosclerosis) :
Neutralization of the IL-8 receptor, CXCR2, further induced
VCAM-1 in the
presence of
IL-1beta , and phospho-p38 was required for NF-kappaB activation and VCAM-1 expression
Luo et al., Toxicol Appl Pharmacol 2009
(Second Messenger Systems) :
Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for
VCAM-1 induction in
IL-1beta treated human tracheal smooth muscle cells ... Here, we investigated the mechanisms underlying
IL-1beta induced
VCAM-1 expression in human tracheal smooth muscle cells ( HTSMCs ) ... These findings suggested that
IL-1beta induced
VCAM-1 expression via these multiple signaling pathways in HTSMCs. Blockade of these pathways may reduce monocyte adhesion via VCAM-1 suppression and attenuation of the inflammatory responses in airway diseases
Chang et al., Eur J Nutr 2010
:
Chlorogenic acid dose-dependently suppressed
IL-1beta induced mRNA expression of
vascular cell adhesion molecule-1 , intercellular cell adhesion molecule-1 and endothelial cell selectin
Yang et al., J Immunol 1994
(Sarcoma, Kaposi...) :
ICAM-1,
VCAM-1 , and E-selectin were all
induced by dsRNA ( poly ( I:C ) ),
IL-1 beta , TNF-alpha, and LPS in KS cells
Nakai et al., Life Sci 1994
:
Estradiol-17 beta regulates the
induction of
VCAM-1 mRNA expression by
interleukin-1 beta in human umbilical vein endothelial cells ... Preincubation with estradiol-17 beta ( 250 or 500 pg/ml ) suppressed the
induction of
VCAM-1 mRNA expression by
interleukin-1 beta ... In conclusion, estradiol-17 beta regulates the
induction of
VCAM-1 gene expression by
interleukin-1 beta in human umbilical vein endothelial cells
Khachigian et al., Biochem Biophys Res Commun 1995
:
Here, we demonstrate that TNF-alpha and
IL-1 beta transiently
induced VCAM-1 mRNA expression in a time dependent manner
Watanabe et al., Biochem Biophys Res Commun 1995
:
Tumor necrosis factor alpha and
interleukin-1 beta but not interferon gamma
induce vascular cell adhesion molecule-1 expression on primary cultured murine hepatocytes ... TNF alpha and
IL-1 beta but not IFN gamma or IL-6
induced VCAM-1 expression on primary cultured murine hepatocytes in a dose- and a time dependent fashion
Wang et al., Atherosclerosis 1995
:
The
IL-1 beta induced expression of intercellular adhesion molecule 1 ( ICAM-1 ),
vascular cell adhesion molecule 1 ( VCAM-1 ) and E-selectin 1 ( ELAM-1 ) on SMCs was examined by reverse transcription/polymerase chain reaction ( RT/PCR )
Offermann et al., Eur J Biochem 1995
:
Although
VCAM-1 is also
induced by the cytokine
interleukin 1 beta (IL-1 beta) , activation of the dsRNA activated protein kinase ( PKR ) occurs only in response to incubation with dsRNA but not with IL-1 beta
Marui et al., J Clin Invest 1993
:
In cultured human umbilical vein endothelial ( HUVE ) cells, the cytokine
interleukin 1 beta (IL-1 beta) activated
VCAM-1 gene expression through a mechanism that was repressed approximately 90 % by the antioxidants pyrrolidine dithiocarbamate ( PDTC ) and N-acetylcysteine (NAC)
Cobb et al., FEBS Lett 1996
:
A benzothiophene-carboxamide is a potent inhibitor of
IL-1beta induced
VCAM-1 gene expression in human endothelial cells
Cobb et al., Eur J Immunol 1996
:
In this report, we investigated the role of the proteasome complex in mediating the interleukin
(IL)- 1 beta induction of
VCAM-1 and ICAM-1 gene expression in human endothelial cells ... We present evidence that a proteasome inhibitor, n-acetyl-leucinyl-leucinyl-norleucinal ( norLEU ), as well as specific protease inhibitors, n-tosyl-Lys-chloromethylketone and N-tosyl-Phe-chloromethylketone, blocked
IL-1 beta induction of
VCAM-1 and ICAM-1 promoter-driven reporter gene expression in stably transfected endothelial cells ... This study demonstrates that inhibition of the proteolytic activity of the proteasome blocks
IL-1 beta induction of
VCAM-1 and ICAM-1 gene expression in human endothelial cells
Del Papa et al., Arthritis Rheum 1996
(Wegener Granulomatosis) :
We found that AECA IgG from WG patients do not display any significant cytotoxicity but are able to up-regulate the expression of E-selectin, intercellular adhesion molecule 1 and
vascular cell adhesion molecule 1 and to
induce the secretion of
IL-1 beta , IL-6, IL-8, and MCP-1
Cobb et al., Mol Pharmacol 1996
:
D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks
interleukin-1 beta induced
vascular cell adhesion molecule 1 gene expression in human endothelial cells ... We investigated the role of phosphatidylcholine-specific phospholipase C in the
induction of
VCAM-1 gene expression by
interleukin-1 beta
Schwarting et al., Scand J Rheumatol 1996
:
In addition, Et-1
enhanced significantly the
IL-1 beta mediated upregulation of VCAM-1 expression, whereas TNF-alpha mediated expression of
VCAM-1 was downregulated by Et-1
Klein et al., Pathobiology 1995
:
In previous studies we have shown that
IL-1 beta and TNF-alpha
increase the expression of ICAM-1, E-selectin and
VCAM-1 on the cytoplasmatic membranes of HUVECs, HSVECs and HAFECs ( ECs from human umbilical vein, saphenous vein and femoral artery, respectively )
Ihm et al., J Korean Med Sci 1996
:
Cell surface enzyme immunoassay showed that INFnu,
IL-1beta , or TNF alpha
stimulated expression of ICAM-1, or
VCAM-1 on MC after 24 hours
Lee et al., J Immunol 1997
:
In this study, we examined the effects of 5-lipoxygenase inhibitors ( nordihydroguaiaretic acid and AA861 ) on
IL-1 beta induced
VCAM-1 gene expression in HUVECs ... We demonstrated that 5-lipoxygenase inhibitors, but not cyclooxygenase inhibitors, block
IL-1 beta induced
VCAM-1 cell surface expression and promoter activity
Braun et al., Arterioscler Thromb Vasc Biol 1997
(Second Messenger Systems) :
In cultured human smooth muscle cells from coronary arteries and saphenous veins, tumor necrosis factor-alpha (TNF-alpha) and
interleukin-1 beta (IL-1 beta) induced the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular cell adhesion molecule (
VCAM-1 ), whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1
Hirata et al., Am J Respir Cell Mol Biol 1998
(Lung Neoplasms) :
TNF-alpha and
IL-1beta increased the expression of ICAM-1, E-selectin, and
VCAM-1 , whereas IL-4 induced only that of VCAM-1
Miller et al., J Leukoc Biol 1998
:
Utilizing neutralizing antibodies, we show that CD40L mediated tissue factor and thrombomodulin modulation, as well as E-selectin and
VCAM-1 upregulation, is
independent of tumor necrosis factor alpha, interleukin-1alpha, or
interleukin-1beta production
Yoshikawa et al., Biofactors 1998
:
PAF induced upregulation of CD11b and CD18 on neutrophils and
IL-1 beta increased surface expression of ICAM-1 and
VCAM-1 on HUVEC ... Coincubation of neutrophils with alpha-Toc and pretreatment of HUVEC with alpha-Toc significantly reduced PAF induced CD11b/CD18 expression and
IL-1 beta induced upregulation of ICAM-1 and
VCAM-1 , respectively
Winkler et al., Glia 1998
:
Astroglioma cell lines as well as primary human fetal astrocytes expressed low levels of
VCAM-1 constitutively, and the proinflammatory cytokines
induced marked increases in VCAM-1 expression, particularly TNF-alpha and
IL-1beta