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PRG4 — PTGS2

Text-mined interactions from Literome

Jouzeau et al., Biorheology 2002 (Cartilage Diseases) : Using L-NMMA ( 1 mM ), as a NO synthase inhibitor, and CuDips ( 10 microM ), as a SOD mimetic, we provide evidence that the inhibitory potency of IL-1beta on proteoglycan synthesis and its stimulating effect on COX-2 activity depend both on NO and O2-* production
Hardy et al., Arthritis Rheum 2002 (Osteoarthritis) : Dexamethasone, neutralizing IL-1 beta antibody, or the selective COX-2 inhibitor, SC-236, attenuated both the IL-1 beta induced PGE ( 2 ) production and cartilage proteoglycan degradation in these cocultures