Gene interactions and pathways from curated databases and text-mining

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CALML3 — NOX4

Text-mined interactions from Literome

Nishina et al., Anesth Analg 2001 (Respiration Disorders...) : CLP increased plasma nitrite/nitrate ( NOx ; stable NO metabolites ), and diaphragm malondialdehyde ( MDA ; a product of lipid peroxidation ), positive immunostaining for nitrotyrosine ( peroxynitrite footprint ), and iNOS activity
Xing et al., Mol Plant Microbe Interact 2001 : Ectopic expression of an Arabidopsis calmodulin-like domain protein kinase enhanced NADPH oxidase activity and oxidative burst in tomato protoplasts
Yu et al., Crit Care Med 2006 (Sepsis) : Thus, propofol ameliorated the CLP induced increases in plasma NOx , basal aortic NOx, and cGMP
Anuar et al., Inflamm Res 2006 (Disease Models, Animal...) : CLP ( 12 h ) reduced blood pressure ( 72.5 +/- 1.0 mm Hg c. f. 101.0 +/- 3.6 mm Hg, P < 0.05 ), and increased plasma NOx ( 153.0 +/- 11.5 muM c. f. 36.2 +/- 3.2 microM, P < 0.05 ), IL-1beta ( 534.0 +/- 93.1 pg/mL c. f. ; 9.6 +/- 9.6 pg/mL, P < 0.05 ), TNF-alpha ( 88.0 +/- 13.6 pg/mL, P < 0.05 ), inflammatory damage in lung and liver, and mortality
Zhou et al., Am J Physiol Regul Integr Comp Physiol 2012 (Peritonitis...) : CLP caused NADPH oxidase activation and endothelial nitric oxide synthase (eNOS) uncoupling to produce superoxide, increased NO production by inducible NOS (iNOS) and neuronal NOS (nNOS) activity, and elevated 3-nitrotyrosine ( a product of peroxynitrite ) formation and PP2A activity in the hindlimb skeletal muscles at 12 h after CLP