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MMP9 — SHH

Text-mined interactions from Literome

Renault et al., J Mol Cell Cardiol 2010 (Corneal Neovascularization) : Our findings indicate that Shh promotes capillary morphogenesis ( tube length on Matrigel increased to 271+/-50 % of the length in untreated cells, p=0.00003 ), induces EC migration ( modified Boyden chamber assay, 191+/-35 % of migration in untreated cells, p=0.00009 ), and increases EC expression of matrix metalloproteinase 9 (MMP-9) and osteopontin (OPN) mRNA ( real-time RT-PCR ), which are essential for Shh induced angiogenesis both in vitro and in vivo
Yoo et al., Cancer Res 2011 (Lymphatic Metastasis...) : Mechanistic investigations revealed that phosphoinositide 3-kinase (PI3K)/Akt inhibition blocked Shh induced epithelial-mesenchyme transition, the activity of matrix metalloproteinase 9 (MMP-9) , and lymphangiogenesis, reducing tumor invasiveness and metastasis