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CSE — MMP9

Text-mined interactions from Literome

Onoue et al., Eur J Biochem 2004 (Pulmonary Disease, Chronic Obstructive) : VIP, at 10 ( -7 ) m, reduced CSE stimulated MMP activity and caspase-3 activation
Kim et al., Exp Mol Med 2009 : In isolated rat AMs, CSE induced MMP-9 expression and phosphorylation of ERK and Akt ... A chemical inhibitor of MEK1/2 or PI3K reduced phosphorylation of ERK or Akt, respectively, and also inhibited CSE mediated MMP-9 induction ... Simvastatin reduced CSE mediated MMP-9 induction, and simvastatin mediated inhibition was reversed by farnesyl pyrophosphate ( FPP ) or geranylgeranyl pyrophosphate ( GGPP ) ... Similar to simvastatin, inhibition of FPP transferase or GGPP transferase suppressed CSE mediated MMP-9 induction ... Taken together, these results suggest that simvastatin may inhibit CSE mediated MMP-9 induction, primarily by blocking prenylation of RAS in the signaling pathways, in which Raf-MEK-ERK, PI3K/Akt, AP-1, and IkappaB-NF-kappaB are involved
Toegel et al., Genes & nutrition 2012 : We further observed that the levels of IL1ß induced MMP-1, MMP-3 , MMP-7, and MMP-9 mRNA, but not TIMP mRNA levels, were down-regulated in chondrocytes in response to CSE
Palozza et al., Inflamm Allergy Drug Targets 2012 : CSE induced a marked increase in MMP-9 expression in cultured as well as in isolated cells ... A 8 h-lycopene pre-treatment ( 0.5-2 µM ) reduced CSE mediated MMP-9 induction in a dose- and time dependent manner ... Taken together, these results suggest that lycopene may inhibit CSE mediated MMP-9 induction, primarily by blocking prenylation of Ras in a signaling pathway, in which MEK1/2-ERK1/2 and NF-?B are involved