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EGR1 — IL8
Text-mined interactions from Literome
Worden et al., Cancer Res 2005
(Carcinoma, Squamous Cell...) :
In the present study, we investigated the potential
role of HGF induced
Egr-1 in expression of PDGF, VEGF, and
IL-8 ... Consistent with this, expression of PDGFA and VEGF but not
IL-8 showed corresponding differences with Egr-1 expression in HNSCC tumor specimens and were strongly
suppressed by transfection of
Egr-1-antisense or small interference RNA ( siRNA ) oligonucleotides
Yoshida et al., Blood Coagul Fibrinolysis 2007
(Carcinoma, Small Cell...) :
Urokinase-type plasminogen activator and interleukin-8 are important biological factors in tumor cell regulation ; STI571 may therefore influence many aspects of tumor cell biology through inducing urokinase-type plasminogen activator and
interleukin-8 , in which the induction of
early growth response-1 expression and extracellular signal regulated kinase 1/2 phosphorylation might be
involved
Moon et al., Biochem Biophys Res Commun 2007
:
DON activated ERK1/2 also mediated the production of early growth response gene 1 (EGR-1) in the epithelial cell line and
EGR-1 had the positive regulatory effect on the
interleukin-8 production in the human epithelial cells
Hoffmann et al., J Biol Chem 2008
(MAP Kinase Signaling System) :
Furthermore, short interfering RNA mediated suppression of
EGR-1 partially
suppresses IL-1-inducible transcription of
IL-8 , IL-6, and CCL2
Mourad-Zeidan et al., Am J Pathol 2008
(Melanoma...) :
Moreover, transient overexpression of
early growth response-1 in C8161-c9 cells
resulted in a loss of vascular endothelial-cadherin and
interleukin-8 promoter activities and protein expression
Ma et al., J Biol Chem 2009
(Neoplasm Invasiveness...) :
Conversely, enforced expression of
EGR-1 in EGR-1 lacking PC3 prostate cancer cells markedly
enhanced IL-8 transcription and secretion ... By using wild type and a series of mutant IL-8 promoter luciferase constructs, we found that the NF-kappaB binding site is important for
EGR-1 regulation of
IL-8
Liu et al., Cell Growth Differ 1993
(Carcinoma, Hepatocellular...) :
Other similar cytokines were investigated, and, of these, only
interleukin 1 could
increase both
Egr-1 and LDL receptor activity