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EGF — ERBB3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of ERBB3-PIK3R1 → EGF (increases) Engelman et al., Proc Natl Acad Sci U S A 2005*
  Evidence: As shown in Fig. 3A, EGF stimulated an association between p85 and ErbB-3 (also observed as the 210-kDa PTyr protein). This association was blocked by exposing the cells to 1 uM gefitinib. Assessment of ErbB-3 immunoprecipitations reveals that gefitinib leads to a decrease in ErbB-3 tyrosine phosphorylation (Fig. 3B Top) and the amount of coprecipitated p85 (Fig. 3B Middle).
• NCI Pathway Database ErbB receptor signaling network: EGF (EGF) → ErbB3 (ERBB3) (modification, collaborate) Marqués et al., Exp Cell Res 1999*, Soltoff et al., Mol Cell Biol 1994*, Kim et al., J Biol Chem 1994*, Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGF (EGF) → EGFR/ErbB3/EGF complex (EGFR-ERBB3-EGF) (modification, collaborate)
  Marqués et al., Exp Cell Res 1999*, Soltoff et al., Mol Cell Biol 1994*, Kim et al., J Biol Chem 1994*, Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: EGFR (EGFR) → EGFR/ErbB3/EGF complex (EGFR-ERBB3-EGF) (modification, collaborate)
  Marqués et al., Exp Cell Res 1999*, Soltoff et al., Mol Cell Biol 1994*, Kim et al., J Biol Chem 1994*, Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: ErbB3 (ERBB3) → EGFR/ErbB3/EGF complex (EGFR-ERBB3-EGF) (modification, collaborate)
  Marqués et al., Exp Cell Res 1999*, Soltoff et al., Mol Cell Biol 1994*, Kim et al., J Biol Chem 1994*, Riese et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• Reactome Reaction: EGF → ERBB3 (reaction) Vijapurkar et al., Exp Cell Res 2003, Walton et al., J Biol Chem 1990, Li et al., Cell Signal 2007, Xu et al., Mol Cell Biol 2007, Hazan et al., Cell Growth Differ 1990, Kaushansky et al., Chem Biol 2008, Helin et al., J Biol Chem 1991, Margolis et al., J Biol Chem 1989, Ricci et al., Oncogene 1995, Wallasch et al., EMBO J 1995, Prigent et al., EMBO J 1994, Soler et al., Oncogene 1994, Segatto et al., Oncogene 1993, Cohen et al., J Biol Chem 1996, Pinkas-Kramarski et al., EMBO J 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EGF — ERBB3 (direct interaction, pull down) Stortelers et al., Biochemistry 2002*
• IRef Hprd Interaction: EGF — ERBB3 (in vitro) Stortelers et al., Biochemistry 2002*
• IRef Ophid Interaction: EGF — ERBB3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Scheving et al., Am J Physiol Gastrointest Liver Physiol 2006 : Although ErbB2 was not present in freshly isolated hepatocytes, EGF and insulin independently induced ErbB2 while suppressing ErbB3 expression
Akl et al., Planta Med 2012 (Breast Neoplasms...) : Western blot studies revealed that combined low-dose treatment of ?-tocotrienol and sesamin caused a marked reduction in EGF induced ErbB3 and ErbB4 receptors phosphorylation ( activation ) and a relatively large decrease in intracellular levels of total and/or phosphorylated c-Raf, MEK1/2, ERK1/2, PI3K, PDK1, Akt, p-NF?B, Jak1, Jak2, and Stat1, as compared to cells treated with only one compound or in the vehicle treated control group
Soltoff et al., Mol Cell Biol 1994 : ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor ... Thus, we show for the first time that ErbB3 can mediate EGF responses in cells expressing both ErbB3 and the EGF receptor
Gamett et al., J Biol Chem 1995 : Like heregulin, epidermal growth factor (EGF) also stimulate the tyrosine phosphorylation of both Neu and ErbB3 ... In the EGF response , at least two tyrosine phosphorylated forms of ErbB3 are detected, but these phosphoproteins have distinctly lower apparent molecular weights compared with the heregulin stimulated ErbB3 phosphoproteins and do not complex with p85
Kim et al., J Biol Chem 1994 (Breast Neoplasms) : In MDA-MB-468 breast cancer cells in which the ErbB3 protein is not constitutively phosphorylated, stimulation with epidermal growth factor led to the phosphorylation of ErbB3 on tyrosine residues and the formation of a functional signal transduction complex involving the ErbB3 protein and PI 3-kinase
Beerli et al., J Biol Chem 1996 (Breast Neoplasms) : Consequently, only NDF, HB-EGF , and BTC significantly stimulated association of phosphatidylinositol kinase activity with ErbB-3
Graus-Porta et al., EMBO J 1997 (Vulvar Neoplasms) : Furthermore, EGF- and BTC induced activation of ErbB-3 is impaired in the absence of ErbB-2, suggesting that ErbB-2 has a role in the lateral transmission of signals between other ErbB receptors