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CNTN2 — ICAM1

Text-mined interactions from Literome

Tanaka et al., Int J Cancer 1995 (Leukemia, T-Cell) : Induction of ICAM-1 and LFA-3 by Tax1 of human T-cell leukemia virus type 1 and mechanism of down-regulation of ICAM-1 or LFA-1 in adult-T-cell-leukemia cell lines
Tanaka et al., J Virol 1996 : Differential transactivation of the intercellular adhesion molecule 1 gene promoter by Tax1 and Tax2 of human T-cell leukemia viruses ... Tax1 strongly activated the ICAM-1 promoter in all the cell lines tested : three T-cell lines ( Jurkat, MOLT-4, and CEM ), one monocytoid cell line ( U937 ), and HeLa ... Unexpectedly, Tax2 activated the ICAM-1 promoter only in HeLa ... By deletion and mutation analyses of the 1.3-kb 5'-flanking region, we found that Tax1 transactivated the ICAM-1 promoter mainly via a cyclic AMP-responsive element ( CRE ) -like site at -630 to -624 in the Jurkat T-cell line and via an NF-kappaB site at -185 to -177 and an SP-1 site at -59 to -54 in HeLa ... Stable expression of Tax1 but not Tax2 in Jurkat subclones enhanced the surface expression of ICAM-1