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GH1 — IL6

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL6 → GH1 (decreases)
  Evidence: Various animal models of genetically determined insulin resistance and obesity, including ob/ob, db/db mice, as well as fa/fa rats, overexpress TNF-? In humans, TNF-? mRNA and protein expression in fat are low but positively correlate with body adiposity, and decrease in obese subjects after weight loss [26, 27]..

Text-mined interactions from Literome

Fasshauer et al., Horm Metab Res 2003 (Insulin Resistance) : Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone , and IL-6 in 3T3-L1 adipocytes
Laing et al., J Appl Physiol 2008 : EX-C blunted the circulating norepinephrine, cortisol, granulocyte-colony stimulating factor, and IL-6 response ( P < 0.01 ) but not the plasma epinephrine and serum growth hormone response
Buzzelli et al., J Trauma 2008 : Nuclear factor kappaB mediates the inhibitory effects of interleukin-1 on growth hormone-inducible gene expression
Gong et al., Chin Med Sci J 2008 (MAP Kinase Signaling System) : Mek and p38 MAPK-dependant pathways are involoved in the positive effect of interleukin-6 on human growth hormone gene expression in rat MtT/S somatotroph cells ... To investigate the effect of interleukin-6 (IL-6) on the human growth hormone ( hGH ) gene expression in a rat somatotropic pituitary cell line MtT/S
Nelson et al., Curr Opin Clin Nutr Metab Care 2008 (Critical Illness) : Music may also increase growth hormone levels, which can induce decreased production of cytokines such as IL-6 by white blood cells
Zhang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2013 : [ Effect of recombinant human growth hormone on the secretion of TNF-a and IL-6 by THP-1 cells and its correlation with the NF-?B pathway ] ... Objective To investigate the effect of recombinant human growth hormone ( rhGH ) on the secretion of TNF-a and IL-6 in THP-1 cells and analyze the correlation between the secretion and NF-?B signaling pathway
Wada et al., Endocrinology 1995 : Inhibitory effects of interleukin-1 on growth hormone secretion in conscious male rats
Swolin et al., J Clin Endocrinol Metab 1996 : Growth hormone increases interleukin-6 produced by human osteoblast-like cells