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IL4 — STAT4

Text-mined interactions from Literome

Schindler et al., J Immunol 2001 : The production of IFN-gamma by IL-12/IL-18 activated macrophages requires STAT4 signaling and is inhibited by IL-4
Chin et al., Nature 2002 (Listeriosis...) : Furthermore, Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells, attributed in part to defective interleukin-12 induced Stat4 activation
Suto et al., J Immunol 2005 : Moreover, IL-4 induced Stat4 expression in PDCs through a Stat6 dependent mechanism, and only the Stat4 expressing PDCs produced IFN-gamma ... These results indicate that PDCs preferentially produce IFN-gamma upon IL-4 stimulation by Stat6- and Stat4 dependent mechanisms
Karpuzoglu et al., Endocrinology 2009 : Signal transducer and activation of transcription ( STAT ) 4beta, a shorter isoform of interleukin-12 induced STAT4 , is preferentially activated by estrogen
Watford et al., J Exp Med 2008 (Toxoplasmosis, Animal) : We investigated the potential roles of Tpl2 in T cells and found that it was induced by interleukin-12 in human and mouse T cells in a Stat4 dependent manner
Aerts et al., Clin Exp Rheumatol 2010 (Arthritis, Rheumatoid) : Peripheral blood mononuclear cells ( PBMC ) were analysed flow cytometrically either directly after isolation or after 24 hours of anti-CD3/anti-CD28 stimulation, to determine spontaneous and IL-4/IL-12 induced STAT4 and STAT6 phosphorylation in CD4+ T cells
Lin et al., Int J Cancer 2012 (Multiple Myeloma) : LLL12 also inhibited STAT3 phosphorylation induced by interleukin-6 (IL-6) and interferon-a but not STAT1, STAT2, STAT4 and STAT6 phosphorylation induced by interferon-a, interferon-? and IL-4 indicating the selectivity of LLL12 for STAT3
Huang et al., Mol Biol Rep 2012 : STAT4 and STAT6 were activated by interleukin (IL)-12 and IL-4 stimulation, which were important for the generation of Th1 and Th2 cells
Thierfelder et al., Nature 1996 : Requirement for Stat4 in interleukin-12 mediated responses of natural killer and T cells
Moriggl et al., J Immunol 1998 : In Th1 cells, IL-12 activated both STAT6 and STAT4 , and IL-4 activated STAT6, but in both cases the Th1 phenotype remained