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CCR3 — IL3

Text-mined interactions from Literome

Iikura et al., J Leukoc Biol 2001 : IL-3 abrogated CXCR4 expression completely, and it only down-regulated CCR2 and CCR3 expression slightly
Dulkys et al., J Immunol 2001 (Calcium Signaling) : In this study, we demonstrate that IL-3 induces a dose- and time dependent down-regulation of CCR3 from the surface of human eosinophils comparable to the CCR3-specific ligand eotaxin, whereas IL-5, GM-CSF, IL-4, IL-10, IL-13, IFN-gamma, and TNF-alpha had no effect ... Maximal down-regulation of CCR3 in response to IL-3 was reached at 24 h. Reduction of CCR3 surface protein in response to IL-3 could be prevented by an anti-IL-3 mAb and was neither due to the release of CC chemokines nor to nonspecific binding of IL-3 to CCR3 ... After 24 h, IL-3 induced decrease of CCR3 surface expression correlated with diminished mRNA expression, suggesting a transcriptional regulation mechanism ... Therefore, these data suggest a novel role for the cytokine IL-3 in the activation process of eosinophils and its predominant chemokine receptor CCR3
Gregory et al., J Immunol 2003 : CCR3 expression was down-regulated by IL-3 and was transiently reduced by IL-5 and GM-CSF, but rapidly returned toward baseline