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AKT3 — CRP
Text-mined interactions from Literome
Nabata et al., Atherosclerosis 2008
(Atherosclerosis) :
Western blot analysis showed that
CRP significantly
attenuated flow mediated activation of
Akt , a key molecule for endothelial cell survival pathways
Schneeweis et al., J Atheroscler Thromb 2010
(Inflammation) :
The observed time course for CRP mediated PTEN upregulation corresponds to the exposure time needed for inhibition of Akt phosphorylation and migration and may therefore constitute a potential mechanism by which
CRP inhibits inducible
Akt phosphorylation and EC migration
Akbar et al., PloS one 2011
(Thrombocytopenia) :
Platelets isolated from Cdc42 ( -/- ), as compared to Cdc42 ( +/+ ), mice exhibited ( a ) diminished phosphorylation of PAK1/2, an effector molecule of Cdc42, ( b ) inhibition of filopodia formation on immobilized CRP or fibrinogen, ( c ) inhibition of CRP- or thrombin induced secretion of ATP and release of P-selectin, ( d ) inhibition of CRP, collagen or thrombin induced platelet aggregation, and ( e ) minimal phosphorylation of
Akt upon
stimulation with
CRP or thrombin