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BCL10 — STAT5A
Text-mined interactions from Literome
Socolovsky et al., Cell 1999
(Anemia) :
Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice : a direct
role for
Stat5 in
Bcl-X ( L ) induction
Dumon et al., Oncogene 1999
:
IL-3 dependent
regulation of
Bcl-xL gene expression by
STAT5 in a bone marrow derived cell line
Lord et al., J Immunol 2000
:
Proliferative signaling by a receptor mutant with a weak Stat5 activating site could be rescued by overexpression of wt Stat5a or b. Additionally, the ability of this receptor mutant to induce c-myc,
bcl-x , and bcl-2 was
enhanced by overexpression of wt
Stat5
Gesbert et al., Blood 2000
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
The increase in transcription of the Bcl-X promoter and the increase in
Bcl-X protein, due to p210 ( Bcr/Abl ), were
blocked by expression of a dominant negative
STAT5 mutant
Donato et al., Blood 2001
(Leukemia) :
Expression of bcr-abl in interleukin-3 (IL-3)/granulocyte-macrophage colony stimulating factor ( GM-CSF ) -dependent Mo7e cells ( MBA ) resulted in growth factor independence, constitutive
activation of
Stat-5 phosphorylation, engagement of mitogen activated protein ( MAP ) kinase signals, and increased expression of PTP1B and
bcl-x ( L )
Walton et al., Mech Dev 2001
:
In erythroid cells
bcl-x gene expression is
controlled by cytokines and the transcription factor
Stat5 ( signal transducer and activator of transcription )
Riedlinger et al., Biol Reprod 2002
:
It has been proposed that
Bcl-x is a key survival factor in many cell types, and that the bcl-x gene is
activated by the transcription factor
Stat5 through cytokine signals ... We have now investigated whether, in the mouse,
Bcl-x is required for the postnatal maintenance of follicles and luteal cells, and whether
Stat5 activates the bcl-x gene ... Furthermore, expression of the
bcl-x gene in the ovary was
independent of
Stat5 and its activating hormone, prolactin
Morcinek et al., Oncogene 2002
:
We identified STAT5 activation as being involved in both growth and survival signalling triggered by the Xmrk kinase possibly due to
STAT5 induced expression of pim-1 and
bcl-x
Versteeg et al., Circ Res 2004
:
In conclusion, our results show that FVIIa induces cell survival through
STAT5 dependent
Bcl ( XL ) production and Jak2 dependent activation of PKB
Goetz et al., J Immunol 2005
:
Thus,
STAT5 dependent
bcl-x ( L ) up-regulation and enhanced B cell survival are not sufficient to drive the thymic B cell development observed in STAT5b-CA mice
Qian et al., Biochim Biophys Acta 2009
(Glioma) :
To determine whether
Stat5 regulates
Bcl-xL expression in CAM induced cell death, C6-glioma was infected with an adenovirus containing a constitutively activated Stat5-GFP ( Ad-Stat5ca ) ... Overexpression of
Stat5ca increased
Bcl-xL and decreased CAM induced cell death compared to control adenovirus infected cells ; whereas Stat5 siRNA decreased DX-induced Bcl-xL and increased cell death
Nagy et al., Molecular cancer 2009
(Lymphoma) :
STAT5 regulation of
BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells