◀ Back to MAPK14
MAPK14 — PLA2G4A
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Gijón et al., J Leukoc Biol 1999
:
In macrophages, zymosan induces a transient increase in intracellular calcium and activation of
MAPK , which together fully
activate cPLA2 and synergistically promote arachidonic acid release
Börsch-Haubold et al., Eur J Biochem 1999
(MAP Kinase Signaling System) :
The inhibitor of
SAPK2a and SAPK2b, SB 202190, completely
blocked collagen induced phosphorylation of
cPLA2 at its two phosphorylation sites in vivo, Ser505 and Ser727
Geijsen et al., FEBS Lett 2000
(MAP Kinase Signaling System) :
Cytokine mediated
cPLA(2) phosphorylation is
regulated by multiple
MAPK family members ... GM-CSF induced
cPLA(2) phosphorylation was not
affected by pharmacological inhibition of p38
MAPK , phosphatidylinositol 3-kinase or Src
Fonteh et al., J Immunol 2000
:
Additionally, an inhibitor of p44/p42
mitogen activated protein kinase ( PD98059 ) significantly
inhibited sPLA2 induced
cPLA2 activation and AA release
Wen et al., J Cell Biochem 2000
:
On the other hand, rottlerin ( the selective PKCdelta inhibitor ), SB 203580 ( the selective p38
MAPK inhibitor ), and wortmannin ( the PI 3-kinase inhibitor ) can
affect neither
cPLA(2) nor ERK phosphorylation
Sano et al., J Immunol 2001
:
Preincubation of eosinophils with U0126 or PD98059, two structurally unrelated
MAPK kinase inhibitors, or arachidonic trifluoromethyl ketone, a
cPLA(2) inhibitor , blocked eosinophil adhesion to FN
Siegel et al., J Biol Chem 2001
(Calcium Signaling...) :
Agonist induced activation of
cPLA2 involves
mitogen activated protein kinase ( MAPK ) activation
Misra et al., Arch Biochem Biophys 2001
(Calcium Signaling...) :
We conclude that alpha2M* induced
cPLA2 synthesis is
controlled by [ Ca2+ ] i levels, tyrosine kinase activity, the p21ras dependent
MAPK and PI 3-kinase downstream signaling pathways, and regulation of NFkappaB
Zhu et al., J Immunol 2001
(MAP Kinase Signaling System) :
We also find that
cPLA(2) activation caused by fMLP occurs subsequent to and is
dependent upon ERK1/2 and p38
MAPK activation
Kalyankrishna et al., J Pharmacol Exp Ther 2003
:
NE-induced p38
MAPK activation was found to be mediated through the stimulation of alpha-1 and alpha-2 adrenergic receptors, was dependent on extracellular Ca ( 2+ ), and was
attenuated by an inhibitor of
cPLA(2) ( pyrrolidine-1 ) ... Moreover, the
cPLA(2) product, AA,
activated p38
MAPK in VSMC
Chakraborti et al., Cell Signal 2003
(MAP Kinase Signaling System) :
Recently, a negative feed back loop for
cPLA(2) activation by
MAPK has been proposed
Li et al., J Pharmacol Exp Ther 2005
:
These data indicate that Ang II-stimulated Akt activity is mediated by
cPLA(2) dependent, p38
MAPK regulated PLD(2) activation and EGFR transactivation
Leoncini et al., Journal of thrombosis and haemostasis : JTH 2006
(Calcium Signaling) :
The
cPLA2 phosphorylation and activation were both
impaired by the inhibition of p38
MAPK through SB203580
Engelbrecht et al., Prostaglandins Leukot Essent Fatty Acids 2007
(MAP Kinase Signaling System...) :
Therefore, the aim of this study was to investigate the
role of
cPLA(2) in
MAPK phosphorylation and apoptosis in simulated ischaemia/reperfusion ( SI/R ) -induced injury in neonatal cardiomyocytes
Kang et al., Int Arch Allergy Immunol 2008
(Anaphylaxis) :
TNF-alpha-induces
cPLA(2) activation through the pathway
involving p38
MAPK and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis
Hoffmann et al., Biochim Biophys Acta 2010
:
Hyperforin induced phosphorylation of
cPLA(2) at Ser505 and activated p38 mitogen activated protein kinase ( MAPK ), and inhibition of p38
MAPK by SB203580
prevented cPLA(2) phosphorylation
Wang et al., Invest Ophthalmol Vis Sci 2011
:
cPLA(2)a is
regulated by calcium mobilization and mitogen activated protein kinases (
MAPK ) activation
Slomiany et al., Inflammopharmacology 2013
:
Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on
MAPK/ERK mediated
activation of IKK-ß and
cPLA2 : modulatory effect of ghrelin
Börsch-Haubold et al., J Biol Chem 1995
:
Collagen, thrombin, and PDBu induced phosphorylation of platelet
cPLA2 as well as
activation of
mitogen activated protein kinase ( MAPK ; p42mapk and p44mapk ) ... Although
MAPK may
underlie phosphorylation of
cPLA2 in PDBu activated human platelets, our results provide evidence for PKC- and MAPK independent phosphorylation of cPLA2 in platelets stimulated by the physiological activators collagen and thrombin
Sa et al., J Biol Chem 1995
:
Since arachidonate release is required for basic FGF stimulated motility of EC, our results show that p42
mitogen activated protein kinase activation of
cPLA2 may be a regulatory event in stimulation of cellular release of this important eicosanoid precursor during cellular responses to basic FGF
Sakanaka et al., Biochem Biophys Res Commun 1994
:
SSTR4 activated
mitogen activated protein ( MAP ) kinase and
induced the phosphorylation of 85kDa
cytosolic phospholipase A2 (cPLA2) , in a PTX-sensitive manner
Hernández et al., Biochem J 1997
(Astrocytoma) :
Evidence that the cytosolic phospholipase A2 (cPLA2) takes part in thrombin induced arachidonate release was provided by the finding that thrombin induced retardation of the mobility of cPLA2 in SDS/polyacrylamide gels, which is a feature of the
activation of
cPLA2 by
mitogen activated protein ( MAP ) kinases
Pyne et al., Biochem J 1997
:
This occurs via a pathway that involves : ( 1 ) the protein kinase C ( PKC ) -dependent activation of
mitogen activated protein kinase ( MAPK); (2 ) the MAPK dependent phosphorylation and
activation of
cytosolic phospholipase A2 (cPLA2) and ( 3 ) the utilization of cPLA2 derived arachidonate by the cyclo-oxygenase pathway to produce prostaglandin E2 ( PGE2 ) ... Acute treatment of ASM cells with PMA ( a direct activator of PKC ) also stimulated the
MAPK dependent phosphorylation of
cPLA2
Hayama et al., J Biochem 1997
:
These data suggest that glucose induced
cPLA2 activation through
MAPK activation is responsible for the enhancement of PGE2 production in mesangial cells
Nakahata et al., Nihon Yakurigaku Zasshi 1997
:
Then, MAPK is activated by a PKC pathway, then
cPLA2 is
activated by
MAPK
Husain et al., Biochim Biophys Acta 1998
:
The data presented are consistent with a
role for PKCalpha, but not for p42/p44
mitogen activated protein kinase ( MAPK ), in
cPLA2 activation and AA release in ET-1 stimulated CISM cells since : ( i ) the PKC inhibitor, RO 31-8220, inhibited ET-1 induced AA release, cPLA2 phosphorylation and cPLA2 activity, but had no inhibitory effect on p42/p44 MAPK activation, ( ii ) genistein, a tyrosine kinase inhibitor, inhibited ET-1 stimulated MAPK activity but had no inhibitory effect on AA release in the ET-1 stimulated cells
Cybulsky et al., Kidney Int 1998
(Glomerulonephritis, Membranous) :
The
role of p42
MAPK in
cPLA2 activation becomes redundant in the presence of relatively potent PKC activation
Pyne et al., Cell Signal 1998
:
cPLA2 is
regulated by
mitogen activated protein kinase ( MAPK ) in a number of cell types