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Blair et al., Am J Physiol Endocrinol Metab 2009
:
A myosin II
ATPase inhibitor
reduces force production, glucose transport, and phosphorylation of
AMPK and TBC1D1 in electrically stimulated rat skeletal muscle
Hallows et al., Am J Physiol Cell Physiol 2009
:
Here we examined whether the metabolic sensor
AMP activated protein kinase (AMPK) regulates this PKA induced
V-ATPase apical membrane accumulation ... In summary, our findings suggest that
AMPK inhibits PKA mediated
V-ATPase apical accumulation in epididymal clear cells, that both kinases directly phosphorylate the V-ATPase A subunit in vitro and in vivo, and that AMPK inhibits PKA dependent phosphorylation of this subunit
Benziane et al., Am J Physiol Cell Physiol 2009
:
The effect of A-769662 on sodium pump is due to direct inhibition of the Na ( + ) -K ( + )
-ATPase activity, rather than
AMPK activation
Gong et al., American journal of physiology. Renal physiology 2010
:
Here, we examined the
regulation of
V-ATPase subcellular localization in intercalated cells by PKA and
AMPK in rat kidney tissue slices ex vivo
Ingwersen et al., J Membr Biol 2011
:
Na,
K-ATPase activity in mouse muscle is
regulated by
AMPK and PGC-1a
Benziane et al., J Biol Chem 2012
:
Whether
AMPK activation
affects Na ( + ), K ( + )
-ATPase activity in skeletal muscle remains to be determined ... Cyanide induced artificial anoxia, as well as a direct
AMPK activator ( A-769662 ) also
increase AMPK phosphorylation and Na ( + ), K ( + )
-ATPase activity ... Moreover, AICAR triggered dephosphorylation of the Na ( + ), K ( + ) -ATPase was prevented in L6 myotubes deficient in PP2A-specific protein phosphatase methylesterase-1 ( PME-1 ), indicating a role for the PP2A·PME-1 complex in
AMPK mediated regulation of Na ( + ), K ( + )
-ATPase