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HIF1A — RAC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: HIF1A → RAC1 (increases, HIF1A Activity)
  Evidence: increases protein - ligands of other receptors (thrombin, angiotensin), RAS expression, small G-protein RAC1, PTEN inhibition, diacyl glycerol kinase

Text-mined interactions from Literome

Hirota et al., J Biol Chem 2001 : We report here that the small GTPase Rac1 is activated in response to hypoxia and is required for the induction of HIF-1alpha protein expression and transcriptional activity in hypoxic cells
Xue et al., Int J Cancer 2006 (Carcinoma, Hepatocellular...) : Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation
Diebold et al., Antioxid Redox Signal 2010 : Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha : a positive-feedback loop promoting pulmonary vascular remodeling