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HIF1A — MYLIP

Text-mined interactions from Literome

Pulkkinen et al., FEBS Lett 2008 (Brain Ischemia) : An active form of the HIF-1alpha induced the expression of miR-210 , showing the involvement of the HIF-1 signaling pathway in miR-210 gene transcription
Taguchi et al., Cancer Res 2008 (Anoxia...) : In this study, we identified hypoxia-inducible factor (HIF)-1 alpha as a novel direct target for miR-17-92 through global expression profiling by mass spectrometric analysis using an isobaric tagging reagent, iTRAQ, combined with bioinformatic target prediction ... In addition, overexpression of c-myc led to down-regulation of HIF-1 alpha and induction of miR-17-92, the latter of which was previously reported to be a transcriptional activation activity, suggesting that the induction of miR-17-92 may play a role at least in part in c-myc mediated repression of HIF-1 alpha
Yeligar et al., J Immunol 2009 : We showed that microRNAs, miR-199 among several microRNAs, attenuated HIF-1alpha and ET-1 expression, while anti-miR-199 reversed the effects, suggesting that ethanol induced miR-199 down-regulation may contribute to augmented HIF-1alpha and ET-1 expression
Lei et al., PloS one 2009 (Anoxia...) : The inhibition of miR-20b increased the protein levels of HIF-1alpha and VEGF in normoxic tumor cells ; the increase of miR-20b in hypoxic tumor cells, nevertheless, decreased the protein levels of HIF-1alpha and VEGF ... Thus, we identify a novel molecular regulation mechanism through which miR-20b regulates HIF-1alpha and VEGF and is regulated by HIF-1alpha so to keep tumor cells adapting to different oxygen concentrations
Cha et al., Cancer Res 2010 (Adenocarcinoma...) : Overexpression of miR-519c resulted in a significant decrease of HIF-1alpha protein levels and reduced the tube formation of human umbilical vein endothelial cells ; similarly, antagomir inhibition of miR-519c increased the level of HIF-1alpha protein and enhanced angiogenic activity, suggesting an important role of miR-519c in HIF-1alpha mediated angiogenesis
Biswas et al., Proc Natl Acad Sci U S A 2010 (Disease Models, Animal...) : In vivo imaging showed massive hypoxia inducible factor-1alpha ( HIF-1alpha ) stabilization in ischemic wounds, where HIF-1alpha induced miR-210 expression that, in turn, silenced its target E2F3, which was markedly down-regulated in the wound-edge tissue of ischemic wounds ... Forced stabilization of HIF-1alpha using Ad-VP16- HIF-1alpha under normoxic conditions up-regulated miR-210 expression, down-regulated E2F3, and limited cell proliferation ... In summary, these results are unique in presenting evidence demonstrating that the hypoxia component of ischemia may limit wound re-epithelialization by stabilizing HIF-1alpha , which induces miR-210 expression, resulting in the down-regulation of the cell-cycle regulatory protein E2F3
Cao et al., Molecular cancer 2010 (Neoplasm Invasiveness...) : In addition, the expression of miR-101 is regulated by androgen receptor and HIF-1alpha/HIF-1beta