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CD40 — TLR4

Text-mined interactions from Literome

Frleta et al., J Leukoc Biol 2003 : CD40 mediated up-regulation of Toll-like receptor 4-MD2 complex on the surface of murine dendritic cells
Curran et al., Cell Immunol 2006 : bLF induced CD40 expression was TLR4 dependent whereas bLF induced IL-6 secretion was TLR4 independent, indicating potentially separate pathways for bLF mediated macrophage activation events in innate immunity
Funderburg et al., Proc Natl Acad Sci U S A 2007 : Here, we show that human beta-defensin-3 (hBD-3), an innate antimicrobial peptide, can induce expression of the costimulatory molecules CD80, CD86, and CD40 , on monocytes and myeloid dendritic cells in a TLR dependent manner
Willart et al., J Exp Med 2009 : This infiltrate was increased when the Toll-like receptor 4 was stimulated and full DC maturation was induced by CD40 triggering
Jones et al., J Immunol 2010 : We compared the ability of progesterone to modulate murine bone marrow derived DC cytokine production ( IL-6 and IL-12 ) and costimulatory molecule expression ( CD40 , CD80, and CD86 ) induced by either TLR3 or TLR4 ligation and determined whether activity was via the progesterone receptor (PR) or glucocorticoid receptor ( GR ) by comparative studies with the PR-specific agonist norgestrel and the GR agonist dexamethasone ... Of particular significance was that progesterone was able to significantly inhibit TLR3- but not TLR4 induced CD40 expression in bone marrow derived DCs
Movita et al., J Leukoc Biol 2012 : Interestingly, despite expression of TLR mRNA on Kupffer cells, ligation of TLR4, TLR7/8 , and TLR9 resulted in a weak induction of IL-10, low or undetectable levels of IL-12p40 and TNF, and up-regulation of CD40 on the surface
Ori et al., J Immunol 2013 : TAB2 and TAB3 are critical for the activation of MAPKs, especially ERK, but not NF-?B, in response to TLR and CD40 stimulation in B cells