Rabadi et al., American journal of physiology. Renal physiology 2012
(MAP Kinase Signaling System) :
Once released, HMGB1 in autocrine fashion promoted further HMGB1 release while also stimulating NF-?B activity and increased angiopoietin-2 expression and protein release
Luo et al., Eur J Cancer 2013
(Colonic Neoplasms...) :
HMGB1 induced tumour necrosis factor-a secretion via Toll-like receptor (TLR)4 in U937 monocytes ; however, HMGB1 decreased the number of U937 cells, resulting in restriction of immune activation via receptor for advanced glycation endproducts ( RAGE )