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SKP2 — TP53

Pathways - manually collected, often from reviews:

• NCI Pathway Database p53 pathway: Cbp/p300/SKP2 complex (EP300_CREBBP-SKP2) → p53 (tetramer) complex (TP53) (modification, inhibits)
  Tang et al., Cell 2008
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Hu et al., Mol Biol Cell 2008 (Melanoma...) : Skp2 regulates G2/M progression in a p53 dependent manner
Chander et al., EMBO Rep 2010 : Here, we report that Skp2B also attenuates the activity of p53 ; however, this effect is independent of p300, suggesting that another mechanism might be involved ... This study indicates that both Skp2 and Skp2B attenuate p53 activity through different pathways, suggesting that amplification of the Skp2 locus represents a powerful mechanism to attenuate p53 function in cancer
Barré et al., Mol Cell 2010 : When Akt is active, GSK3beta is repressed, allowing p52 and p53 to cooperatively induce Skp2 expression