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CD44 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
TP53
—
CD44
(interaction, mapped from intact)
-
STRING interaction:
CD44
—
TP53
(interaction, mapped from intact)
Text-mined interactions from Literome
Godar et al., Cell 2008
:
Here, we show that under conditions of basal physiologic and cell-culture stress,
p53 inhibits expression of the
CD44 cell-surface molecule via binding to a noncanonical p53 binding sequence in the CD44 promoter
Sohr et al., Cell cycle (Georgetown, Tex.) 2008
:
Additionally, p53 dependent downregulation is consistent with an oncogenic function of RHAMM and the recently reported tumor-suppressive function of
CD44 transcriptional
repression by
p53
Mandal et al., J Biol Chem 2011
(Bone Neoplasms...) :
shRNA derived inhibition of mutant
p53R280K augmented the expression of
CD44 , leading to increased migration and invasion
Ren et al., Int J Oncol 2013
(Prostatic Neoplasms) :
Moreover,
WT-p53 also
suppressed colony formation, tumor sphere formation and expression of CSC markers and stemness factors including
CD44 , Oct4, c-Myc and Klf4 in PC-3 cells
Zeilstra et al., PloS one 2013
:
In the present study, we therefore explored the relation between p53 mutational status and CD44 expression in a cohort of 90 localized primary CRCs and studied the
effect of radiation induced
p53 activation on
CD44 expression ... Our data demonstrate that
CD44 expression in normal and malignant intestinal epithelial cells is not
regulated by
p53 , implying that regulation of this potentially important therapeutic target is tissue and cancer-type specific