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C1ORF228 — EPHB2

Text-mined interactions from Literome

Correa et al., Br J Pharmacol 2005 : 3 The inhibitory effect of JWH-133 ( 100 nM ) on IL-12p40 production may involve extracellular regulated kinase ( ERK1/2 ) signaling : ( i ) JWH-133 induced a greater and sustained activation of ERK1/2 kinase in comparison with the level of activation observed following LPS ; ( ii ) the inhibition of ERK1/2 by the specific inhibitor PD98059 increased LPS induced IL-12p40 production in the presence or absence of JWH-133 suggesting a negative regulation of ERK pathway on IL-12p40 biosynthesis
Tomczak et al., J Immunol 2006 (MAP Kinase Signaling System) : Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus ... These results suggest that H. hepaticus induces ERK activation by a pathway dependent upon Tpl-2 and p105, and that activation of ERK inhibits the expression of IL-12 p40 by inducing c-Fos
Zhao et al., PloS one 2012 : The C-terminal region of p105 is necessary for LPS induced ERK activation and it has been suggested that ERK activity inhibits both IFN-ß and IL-12 p40 following LPS stimulation
Zhang et al., Cell Mol Immunol 2012 : Furthermore, Ras-guanine nucleotide releasing protein 1 ( RasGRP1 ) mediated the TLR2 induced ERK1/2 activation and inhibition of IL-12p40 production