◀ Back to EGFR

EGFR — GAB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of GAB1-SYP → EGFR (directlyIncreases, GAB1/SYP Activity) Lehr et al., Biochemistry 2000*
  Evidence: Recently, we identified a similar cohort of tyrosine phosphorylation sites for the epidermal growth factor receptor (EGFR) with a predominant phosphorylation of tyrosine residue Y657 and binding of Syp [Lehr, S. et al. (1999) Biochemistry 38, 151-159].
• OpenBEL Selventa BEL large corpus: GAB1 → EGFR (increases) Badache et al., Cancer Res 2001*
  Evidence: Pretreating the cells with EGF receptor specific antibody, mAb 528 or with the EGF receptor specific inhibitor CGP59326 resulted in decreased phosphorylation of GAB1, and also decreased association with the other members of the immune complex including the EGF receptor.
• OpenBEL Selventa BEL large corpus: GAB1 → EGFR (directlyIncreases, GAB1 Activity)
  Evidence: Gab-1 is heavily phosphorylated by the epidermal growth factor receptor, but poorly by the insulin receptor
• OpenBEL Selventa BEL large corpus: GAB1 → EGFR (directlyIncreases, GAB1 Activity)
  Evidence: 10978177;9890893;10734310
• OpenBEL Selventa BEL large corpus: GAB1 → EGFR (directlyIncreases, GAB1 Activity)
  Evidence: 10978177;9890893;10753869;10734310
• OpenBEL Selventa BEL large corpus: GAB1 → EGFR (directlyIncreases, GAB1 Activity) Lehr et al., Biochemistry 2000*
  Evidence: Recently, we identified a similar cohort of tyrosine phosphorylation sites for the epidermal growth factor receptor (EGFR) with a predominant phosphorylation of tyrosine residue Y657 and binding of Syp [Lehr, S. et al. (1999) Biochemistry 38, 151-159].
• NCI Pathway Database Signaling events mediated by TCPTP: TCPTP p45 (PTPN2) → EGFR/EGFR/EGF/EGF/GRB2/GAB1 complex (EGFR-EGF-GRB2-GAB1) (modification, activates)
  Tiganis et al., J Biol Chem 1999*, Lam et al., J Biol Chem 2001*, Tiganis et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database LPA receptor mediated events: Gab1 (GAB1) → EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1) (modification, collaborate)
  Laffargue et al., J Biol Chem 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database LPA receptor mediated events: Gab1 (GAB1) → EGFR (EGFR) (modification, collaborate) Laffargue et al., J Biol Chem 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database LPA receptor mediated events: EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1) → EGFR (EGFR) (modification, collaborate) Laffargue et al., J Biol Chem 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database LPA receptor mediated events: EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1) → PI3K-beta complex (PIK3CB-PIK3R1) (modification, collaborate)
  Laffargue et al., J Biol Chem 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database SHP2 signaling: EGFR/EGFR/EGF/EGF/GNAI1/GNAI3/GAB1 complex (EGFR-EGF-GNAI1-GNAI3-GAB1) → SHP2 (PTPN11) (translocation, activates) Yart et al., J Biol Chem 2001
  Evidence: physical interaction
• NCI Pathway Database LPA receptor mediated events: EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1) → None (modification, activates) Laffargue et al., J Biol Chem 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database LPA receptor mediated events: EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1) (modification, activates) Laffargue et al., J Biol Chem 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database SHP2 signaling: SHP2 (PTPN11) → EGFR/EGFR/EGF/EGF/GRB2/GAB1 complex (EGFR-EGF-GRB2-GAB1) (modification, activates)
  Zhang et al., Mol Cell Biol 2002*, Montagner et al., J Biol Chem 2005
  Evidence: mutant phenotype, assay, physical interaction, other species
• Reactome Reaction: EGFR → GAB1 (indirect_complex) Rodrigues et al., Mol Cell Biol 2000, Gual et al., Oncogene 2000, Lock et al., J Biol Chem 2000*, Cunnick et al., J Biol Chem 2001*, Agazie et al., Mol Cell Biol 2003, Kapoor et al., Mol Cell Biol 2004*, Jackson et al., Cancer Res 2004, Lynch et al., N Engl J Med 2004, Fan et al., J Biol Chem 2004*, Sordella et al., Science 2004, Pao et al., Proc Natl Acad Sci U S A 2004, Greulich et al., PLoS Med 2005, Yang et al., Cancer Res 2006, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997, Lehr et al., Biochemistry 1999*
• Reactome Reaction: EGFR → GAB1 (reaction) Gual et al., Oncogene 2000, Lock et al., J Biol Chem 2000*, Agazie et al., Mol Cell Biol 2003, Jackson et al., Cancer Res 2004, Lynch et al., N Engl J Med 2004, Fan et al., J Biol Chem 2004*, Sordella et al., Science 2004, Pao et al., Proc Natl Acad Sci U S A 2004, Greulich et al., PLoS Med 2005, Yang et al., Cancer Res 2006, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997, Lehr et al., Biochemistry 1999*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: GAB1 — EGFR (physical association, affinity chromatography technology) Tong et al., J Proteome Res 2008
• IRef Biogrid Interaction: GAB1 — EGFR (physical association, affinity chromatography technology) Kameda et al., Cell Growth Differ 2001*
• IRef Hprd Interaction: GAB1 — EGFR (in vivo) Gual et al., Oncogene 2000, Kameda et al., Cell Growth Differ 2001*
• IRef Hprd Interaction: GAB1 — EGFR (in vitro) Gual et al., Oncogene 2000, Kameda et al., Cell Growth Differ 2001*
• IRef Intact Interaction: Complex of GAB1-SHC1-GRB2-EGFR (association, anti bait coimmunoprecipitation) Jung et al., Oncogene 2011
• IRef Ophid Interaction: GAB1 — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• STRING interaction: GAB1 — EGFR (interaction, mapped from kegg_pathways)
• STRING interaction: GAB1 — EGFR (interaction, mapped from kegg_pathways)
• STRING interaction: EGFR — GAB1 (interaction, mapped from kegg_pathways)
• STRING interaction: EGFR — GAB1 (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Rodrigues et al., Mol Cell Biol 2000 : The PH domain of Gab1 was shown to bind specifically to phosphatidylinositol 3,4,5-triphosphate [ PtdIns ( 3,4,5 ) P3 ], a product of PI-3 kinase, and is required for activation of Gab1 mediated enhancement of EGFR signaling
Gillgrass et al., Oncogene 2003 (Disease Progression...) : Epidermal growth factor receptor dependent activation of Gab1 is involved in ErbB-2 mediated mammary tumor progression ... These observations provide evidence that efficient ErbB-2 induced mammary tumor progression requires EGFR dependent activation of Gab1
Kapoor et al., Mol Cell Biol 2004 (Glioblastoma) : Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells
Sampaio et al., Mol Cell Biol 2008 : Indeed, by up- and down-regulation of signal strength in different cell lines and through different methods, we observed that Gab1/Shp2 and Ras/ERK1-2 in concert become independent of PI3K upon strong epidermal growth factor receptor (EGFR) stimulation and dependent on PI3K upon limited EGFR activation
Daub et al., EMBO J 1997 : Transient expression of either Gq- or Gi-coupled receptors in COS-7 cells allowed GPCR agonist induced EGFR transactivation, and lysophosphatidic acid (LPA) generated signals involved the docking protein Gab1